I7MMA3_TETTS protein (Tetrahymena thermophila)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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I7MMA3_TETTS

Poly (ADP-ribose) glycohydrolase. (790 aa)

Predicted Functional Partners:

I7LXZ8_TETTS

0.513

I7LZH7_TETTS

0.513

I7MCG2_TETTS

0.513

I7MGV0_TETTS

0.513

I7MIX3_TETTS

0.513

Q22MT0_TETTS

0.513

Q22XV4_TETTS

0.513

Q23G55_TETTS

0.513

Q23M88_TETTS

0.513

Q24FE8_TETTS

0.513

Your Current Organism:

Tetrahymena thermophila

NCBI taxonomy Id: 312017
Other names: T. thermophila SB210, Tetrahymena thermophila SB210

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I7LXZ8_TETTS	I7MMA3_TETTS	I7LXZ8	I7MMA3	Poly polymerase and DNA-ligase Zn-finger region family protein.	Poly (ADP-ribose) glycohydrolase.	0.513
I7LZH7_TETTS	I7MMA3_TETTS	I7LZH7	I7MMA3	Poly polymerase and DNA-ligase Zn-finger region family protein.	Poly (ADP-ribose) glycohydrolase.	0.513
I7MCG2_TETTS	I7MMA3_TETTS	I7MCG2	I7MMA3	Poly [ADP-ribose] polymerase.	Poly (ADP-ribose) glycohydrolase.	0.513
I7MGV0_TETTS	I7MMA3_TETTS	I7MGV0	I7MMA3	Poly [ADP-ribose] polymerase.	Poly (ADP-ribose) glycohydrolase.	0.513
I7MIX3_TETTS	I7MMA3_TETTS	I7MIX3	I7MMA3	Poly polymerase and DNA-ligase Zn-finger region family protein, putative.	Poly (ADP-ribose) glycohydrolase.	0.513
I7MMA3_TETTS	I7LXZ8_TETTS	I7MMA3	I7LXZ8	Poly (ADP-ribose) glycohydrolase.	Poly polymerase and DNA-ligase Zn-finger region family protein.	0.513
I7MMA3_TETTS	I7LZH7_TETTS	I7MMA3	I7LZH7	Poly (ADP-ribose) glycohydrolase.	Poly polymerase and DNA-ligase Zn-finger region family protein.	0.513
I7MMA3_TETTS	I7MCG2_TETTS	I7MMA3	I7MCG2	Poly (ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.513
I7MMA3_TETTS	I7MGV0_TETTS	I7MMA3	I7MGV0	Poly (ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.513
I7MMA3_TETTS	I7MIX3_TETTS	I7MMA3	I7MIX3	Poly (ADP-ribose) glycohydrolase.	Poly polymerase and DNA-ligase Zn-finger region family protein, putative.	0.513
I7MMA3_TETTS	Q22MT0_TETTS	I7MMA3	Q22MT0	Poly (ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.513
I7MMA3_TETTS	Q22XV4_TETTS	I7MMA3	Q22XV4	Poly (ADP-ribose) glycohydrolase.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.513
I7MMA3_TETTS	Q23G55_TETTS	I7MMA3	Q23G55	Poly (ADP-ribose) glycohydrolase.	Poly polymerase and DNA-ligase Zn-finger region family protein.	0.513
I7MMA3_TETTS	Q23M88_TETTS	I7MMA3	Q23M88	Poly (ADP-ribose) glycohydrolase.	Poly polymerase and DNA-ligase Zn-finger region family protein.	0.513
I7MMA3_TETTS	Q24FE8_TETTS	I7MMA3	Q24FE8	Poly (ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.513
Q22MT0_TETTS	I7MMA3_TETTS	Q22MT0	I7MMA3	Poly [ADP-ribose] polymerase.	Poly (ADP-ribose) glycohydrolase.	0.513
Q22XV4_TETTS	I7MMA3_TETTS	Q22XV4	I7MMA3	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	Poly (ADP-ribose) glycohydrolase.	0.513
Q23G55_TETTS	I7MMA3_TETTS	Q23G55	I7MMA3	Poly polymerase and DNA-ligase Zn-finger region family protein.	Poly (ADP-ribose) glycohydrolase.	0.513
Q23M88_TETTS	I7MMA3_TETTS	Q23M88	I7MMA3	Poly polymerase and DNA-ligase Zn-finger region family protein.	Poly (ADP-ribose) glycohydrolase.	0.513
Q24FE8_TETTS	I7MMA3_TETTS	Q24FE8	I7MMA3	Poly [ADP-ribose] polymerase.	Poly (ADP-ribose) glycohydrolase.	0.513

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.851

expected number of edges:

11

PPI enrichment p-value:

3.64e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015031

Protein transport

6 of 102

1.42

1.54

5.95e-05

GO:0007059

Chromosome segregation

2 of 10

1.95

0.77

0.0357

GO:0006810

Transport

7 of 642

0.69

0.44

0.0221

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031992

Energy transducer activity

2 of 3

2.47

0.8

0.0355

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005887

Integral component of plasma membrane

3 of 54

1.39

0.7

0.0310

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37425997

(2023) Polymeric carbohydrates utilization separates microbiomes into niches: insights into the diversity of microbial carbohydrate-active enzymes in the inner shelf of the Pearl River Estuary, China.

2 of 3

2.47

1.15

0.0078

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5389

Mixed, incl. MotA/TolQ/ExbB proton channel, and Protein of unknown function (DUF3450)

10 of 13

2.54

9.46

5.84e-21

CL:5392

MotA/TolQ/ExbB proton channel, and Protein of unknown function (DUF3450)

5 of 5

2.65

4.88

4.64e-10

CL:5403

Mixed, incl. MotA/TolQ/ExbB proton channel, and Protein of unknown function (DUF3450)

3 of 6

2.35

2.21

6.11e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0653

Protein transport

6 of 36

1.87

3.16

2.77e-08

KW-0735

Signal-anchor

2 of 4

2.35

1.23

0.0052

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03544

Gram-negative bacterial TonB protein C-terminal

3 of 8

2.22

1.59

0.00098

PF01618

MotA/TolQ/ExbB proton channel family

3 of 8

2.22

1.59

0.00098

PF11932

Protein of unknown function (DUF3450)

2 of 2

2.65

1.2

0.0065

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037682

TonB, C-terminal

3 of 8

2.22

1.38

0.0025

IPR006260

TonB/TolA, C-terminal

3 of 8

2.22

1.38

0.0025

IPR002898

MotA/TolQ/ExbB proton channel

3 of 8

2.22

1.38

0.0025

IPR017270

Putative MotA/TolQ/ExbB family protein

2 of 2

2.65

1.05

0.0124

IPR016866

Uncharacterised conserved protein UCP028069

2 of 2

2.65

1.05

0.0124

(more ...)

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