STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Q22U13_TETTSFlavin containing family amine oxidase. (449 aa)    
Predicted Functional Partners:
HHF1
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.685
Q23F99_TETTS
Squalene/phytoene synthase.
   
 
 0.658
I7LUZ3_TETTS
Histone H3; Belongs to the histone H3 family.
    
 0.649
HHT3
Histone H3.3; Macronuclear replacement variant which replaces conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Functions redundantly to H3.4. H3.3 deposition into chromatin is mainly tran [...]
    
 0.649
HHT4
Histone H3.4; Macronuclear replacement variant which replaces conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Functions redundantly to H3.3. H3.4 deposition is mainly transcription-assoc [...]
    
 0.649
CNA1
Histone H3-like centromeric protein CNA1; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
    
 0.649
A4VDD9_TETTS
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
   
 0.639
I7LWK7_TETTS
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
   
 0.639
I7M8W6_TETTS
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
   
 0.639
W7XBN4_TETTS
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
   
 0.639
Your Current Organism:
Tetrahymena thermophila
NCBI taxonomy Id: 312017
Other names: T. thermophila SB210, Tetrahymena thermophila SB210
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.