STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Q245K9_TETTSHistone acetyltransferase GCN5. (418 aa)    
Predicted Functional Partners:
HHF1
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.999
Q24DR4_TETTS
Transcriptional adapter.
  
 0.999
W7XJC9_TETTS
Transcription initiation factor TFIID 23-30 kDa subunit.
    
 0.999
I7M9J4_TETTS
Ubiquitin carboxyl-terminal hydrolase.
    
 0.998
Q23ZC7_TETTS
TATA box-binding protein associated factor.
   
 0.998
W7XCD5_TETTS
Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]
    
 0.998
I7LUZ3_TETTS
Histone H3; Belongs to the histone H3 family.
    
 0.996
Q22HG6_TETTS
Mov34/MPN/PAD-1 family protein.
    
 0.992
Q23JI0_TETTS
Transformation/transcription domain associated protein, putative.
    
 0.987
Q23JI1_TETTS
Transformation transcription domain associated protein, putative.
    
 0.987
Your Current Organism:
Tetrahymena thermophila
NCBI taxonomy Id: 312017
Other names: T. thermophila SB210, Tetrahymena thermophila SB210
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.