EAR25073.1 protein (actinobacterium PHSC20C1)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

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Score

EAR25073.1

Hypothetical protein. (294 aa)

Predicted Functional Partners:

argS

0.806

EAR25075.1

0.571

lysA

0.567

thrB

0.563

EAR25071.1

0.553

EAR25076.1

0.548

Your Current Organism:

actinobacterium PHSC20C1

NCBI taxonomy Id: 312284
Other names: m. actinobacterium PHSC20C1, marine actinobacterium PHSC20C1, marine actinobacterium str. PHSC20C1, marine actinobacterium strain PHSC20C1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR25071.1	EAR25073.1	A20C1_00746	A20C1_00756	arginyl-tRNA synthetase.	Hypothetical protein.	0.553
EAR25071.1	argS	A20C1_00746	A20C1_00751	arginyl-tRNA synthetase.	COG0018 Arginyl-tRNA synthetase.	0.570
EAR25073.1	EAR25071.1	A20C1_00756	A20C1_00746	Hypothetical protein.	arginyl-tRNA synthetase.	0.553
EAR25073.1	EAR25075.1	A20C1_00756	A20C1_00766	Hypothetical protein.	COG0460 Homoserine dehydrogenase.	0.571
EAR25073.1	EAR25076.1	A20C1_00756	A20C1_00771	Hypothetical protein.	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	0.548
EAR25073.1	argS	A20C1_00756	A20C1_00751	Hypothetical protein.	COG0018 Arginyl-tRNA synthetase.	0.806
EAR25073.1	lysA	A20C1_00756	A20C1_00761	Hypothetical protein.	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.	0.567
EAR25073.1	thrB	A20C1_00756	A20C1_00776	Hypothetical protein.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.563
EAR25075.1	EAR25073.1	A20C1_00766	A20C1_00756	COG0460 Homoserine dehydrogenase.	Hypothetical protein.	0.571
EAR25075.1	EAR25076.1	A20C1_00766	A20C1_00771	COG0460 Homoserine dehydrogenase.	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	0.994
EAR25075.1	argS	A20C1_00766	A20C1_00751	COG0460 Homoserine dehydrogenase.	COG0018 Arginyl-tRNA synthetase.	0.615
EAR25075.1	lysA	A20C1_00766	A20C1_00761	COG0460 Homoserine dehydrogenase.	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.	0.978
EAR25075.1	thrB	A20C1_00766	A20C1_00776	COG0460 Homoserine dehydrogenase.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.999
EAR25076.1	EAR25073.1	A20C1_00771	A20C1_00756	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	Hypothetical protein.	0.548
EAR25076.1	EAR25075.1	A20C1_00771	A20C1_00766	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	COG0460 Homoserine dehydrogenase.	0.994
EAR25076.1	argS	A20C1_00771	A20C1_00751	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	COG0018 Arginyl-tRNA synthetase.	0.642
EAR25076.1	lysA	A20C1_00771	A20C1_00761	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.	0.852
EAR25076.1	thrB	A20C1_00771	A20C1_00776	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.998
argS	EAR25071.1	A20C1_00751	A20C1_00746	COG0018 Arginyl-tRNA synthetase.	arginyl-tRNA synthetase.	0.570
argS	EAR25073.1	A20C1_00751	A20C1_00756	COG0018 Arginyl-tRNA synthetase.	Hypothetical protein.	0.806

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.919

expected number of edges:

11

PPI enrichment p-value:

0.145

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901607

Alpha-amino acid biosynthetic process

9 of 97

1.48

2.54

8.52e-10

GO:0006566

Threonine metabolic process

3 of 11

1.94

1.68

0.00040

GO:0044283

Small molecule biosynthetic process

10 of 217

1.17

1.64

3.96e-09

GO:0009070

Serine family amino acid biosynthetic process

3 of 16

1.78

1.45

0.00094

GO:0006563

L-serine metabolic process

2 of 8

1.91

0.97

0.0132

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004834

Tryptophan synthase activity

3 of 3

2.51

1.9

0.00030

GO:0016841

Ammonia-lyase activity

3 of 5

2.29

1.86

0.00030

GO:0030170

Pyridoxal phosphate binding

4 of 35

1.57

1.38

0.00066

GO:0004794

L-threonine ammonia-lyase activity

2 of 2

2.51

1.28

0.0044

GO:0016829

Lyase activity

6 of 116

1.22

1.16

0.00030

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1074

Glycine, serine and threonine metabolism

6 of 13

2.17

4.17

1.16e-09

CL:1073

Cysteine and methionine metabolism, and Pyridoxal-phosphate dependent enzyme

7 of 23

1.99

4.04

2.89e-10

CL:1070

Biosynthesis of amino acids

9 of 90

1.51

2.7

2.89e-10

CL:1076

Threonine biosynthesis, and Threonine synthase-like

2 of 6

2.03

0.83

0.0272

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tbi00260

Glycine, serine and threonine metabolism

11 of 31

2.06

7.05

1.58e-20

tbi01230

Biosynthesis of amino acids

10 of 113

1.46

2.82

9.54e-13

tbi01110

Biosynthesis of secondary metabolites

11 of 301

1.07

1.48

7.03e-11

tbi01200

Carbon metabolism

5 of 85

1.28

1.34

7.99e-05

tbi00400

Phenylalanine, tyrosine and tryptophan biosynthesis

3 of 25

1.59

1.31

0.0012

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

8 of 401

0.81

0.66

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0822

Tryptophan biosynthesis

3 of 6

2.21

1.94

0.00018

KW-0028

Amino-acid biosynthesis

5 of 61

1.42

1.44

0.00016

KW-0663

Pyridoxal phosphate

3 of 35

1.44

0.96

0.0069

KW-0456

Lyase

4 of 79

1.21

0.9

0.0040

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00291

Pyridoxal-phosphate dependent enzyme

5 of 8

2.3

3.58

6.80e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036052

Tryptophan synthase beta chain-like, PALP domain superfamily

5 of 8

2.3

3.39

1.84e-07

IPR001926

Tryptophan synthase beta chain-like, PALP domain

5 of 8

2.3

3.39

1.84e-07

IPR023026

Tryptophan synthase beta chain/beta chain-like

2 of 2

2.51

0.87

0.0257

IPR006654

Tryptophan synthase, beta chain

2 of 2

2.51

0.87

0.0257

IPR006653

Tryptophan synthase, beta chain, conserved site

2 of 2

2.51

0.87

0.0257

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