node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAR24319.1 | EAR25188.1 | A20C1_00490 | A20C1_01331 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.449 |
EAR24319.1 | EAR25489.1 | A20C1_00490 | A20C1_04461 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | COG0285 Folylpolyglutamate synthase. | 0.985 |
EAR24319.1 | EAR25804.1 | A20C1_00490 | A20C1_07988 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.988 |
EAR24319.1 | EAR25805.1 | A20C1_00490 | A20C1_07993 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.991 |
EAR24319.1 | folE | A20C1_00490 | A20C1_08003 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | COG0302 GTP cyclohydrolase I. | 0.940 |
EAR24319.1 | thyA | A20C1_00490 | A20C1_01326 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.545 |
EAR25188.1 | EAR24319.1 | A20C1_01331 | A20C1_00490 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.449 |
EAR25188.1 | EAR25489.1 | A20C1_01331 | A20C1_04461 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | COG0285 Folylpolyglutamate synthase. | 0.958 |
EAR25188.1 | EAR25806.1 | A20C1_01331 | A20C1_07998 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | COG0294 Dihydropteroate synthase and related enzymes. | 0.449 |
EAR25188.1 | thyA | A20C1_01331 | A20C1_01326 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
EAR25487.1 | EAR25488.1 | A20C1_04451 | A20C1_04456 | COG0105 Nucleoside diphosphate kinase. | Membrane protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | 0.828 |
EAR25487.1 | EAR25489.1 | A20C1_04451 | A20C1_04461 | COG0105 Nucleoside diphosphate kinase. | COG0285 Folylpolyglutamate synthase. | 0.862 |
EAR25487.1 | folE | A20C1_04451 | A20C1_08003 | COG0105 Nucleoside diphosphate kinase. | COG0302 GTP cyclohydrolase I. | 0.862 |
EAR25487.1 | ileS | A20C1_04451 | A20C1_04466 | COG0105 Nucleoside diphosphate kinase. | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | 0.825 |
EAR25488.1 | EAR25487.1 | A20C1_04456 | A20C1_04451 | Membrane protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | COG0105 Nucleoside diphosphate kinase. | 0.828 |
EAR25488.1 | EAR25489.1 | A20C1_04456 | A20C1_04461 | Membrane protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | COG0285 Folylpolyglutamate synthase. | 0.885 |
EAR25488.1 | ileS | A20C1_04456 | A20C1_04466 | Membrane protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | 0.816 |
EAR25489.1 | EAR24319.1 | A20C1_04461 | A20C1_00490 | COG0285 Folylpolyglutamate synthase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.985 |
EAR25489.1 | EAR25188.1 | A20C1_04461 | A20C1_01331 | COG0285 Folylpolyglutamate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.958 |
EAR25489.1 | EAR25487.1 | A20C1_04461 | A20C1_04451 | COG0285 Folylpolyglutamate synthase. | COG0105 Nucleoside diphosphate kinase. | 0.862 |