STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EAR25531.1DNA glycosylase; COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (332 aa)    
Predicted Functional Partners:
EAR23864.1
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
0.892
EAR25750.1
DNA glycosylase; COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family.
  
  
 
0.878
EAR25532.1
COG0698 Ribose 5-phosphate isomerase RpiB.
       0.816
EAR24291.1
COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains.
  
  
 0.804
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.804
EAR23672.1
COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains.
  
  
 0.804
EAR25530.1
COG2808 Transcriptional regulator.
       0.786
EAR25529.1
Conserved protein, putative metal-dependent hydrolase; COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold.
       0.780
EAR25533.1
COG0308 Aminopeptidase N.
       0.633
EAR25749.1
COG1201 Lhr-like helicases.
  
  
 0.618
Your Current Organism:
actinobacterium PHSC20C1
NCBI taxonomy Id: 312284
Other names: m. actinobacterium PHSC20C1, marine actinobacterium PHSC20C1, marine actinobacterium str. PHSC20C1, marine actinobacterium strain PHSC20C1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.