STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EAR24857.1Hypothetical protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (214 aa)    
Predicted Functional Partners:
EAR24387.1
COG4805 Uncharacterized protein conserved in bacteria.
     0.769
EAR25399.1
Transcriptional regulator, NifR3/Smm1 family protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.
 
     0.719
EAR24856.1
23S rRNA methyltransferase/RumA; COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
 
     0.690
kynA
Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
    
   0.662
EAR24858.1
Biotin carboxylase; COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit.
       0.607
EAR24853.1
Hypothetical protein; COG0466 ATP-dependent Lon protease, bacterial type.
       0.467
lipA
Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
   
  
 0.436
EAR24854.1
Two-component system, sensor protein; COG0477 Permeases of the major facilitator superfamily.
       0.425
EAR24855.1
Putative two-component system response regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.
       0.420
EAR24859.1
Serine protease, subtilase family protein; COG1404 Subtilisin-like serine proteases; Belongs to the peptidase S8 family.
 
     0.418
Your Current Organism:
actinobacterium PHSC20C1
NCBI taxonomy Id: 312284
Other names: m. actinobacterium PHSC20C1, marine actinobacterium PHSC20C1, marine actinobacterium str. PHSC20C1, marine actinobacterium strain PHSC20C1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.