EAR24901.1 protein (actinobacterium PHSC20C1)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

EAR24901.1

Hypothetical protein; COG1316 Transcriptional regulator. (190 aa)

Predicted Functional Partners:

EAR24902.1

0.818

EAR25615.1

0.744

EAR24527.1

0.718

EAR24576.1

0.712

EAR25084.1

0.697

EAR26147.1

0.687

EAR24215.1

0.661

lysS

0.655

EAR26135.1

0.648

EAR24995.1

0.642

Your Current Organism:

actinobacterium PHSC20C1

NCBI taxonomy Id: 312284
Other names: m. actinobacterium PHSC20C1, marine actinobacterium PHSC20C1, marine actinobacterium str. PHSC20C1, marine actinobacterium strain PHSC20C1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR24215.1	EAR24527.1	A20C1_12244	A20C1_12887	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	Exodeoxyribonuclease VII small subunit.	0.422
EAR24215.1	EAR24901.1	A20C1_12244	A20C1_06456	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	Hypothetical protein; COG1316 Transcriptional regulator.	0.661
EAR24215.1	EAR24995.1	A20C1_12244	A20C1_06926	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases.	0.685
EAR24215.1	EAR25084.1	A20C1_12244	A20C1_00811	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	Membrane protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.	0.461
EAR24215.1	EAR25615.1	A20C1_12244	A20C1_05091	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	Hypothetical protein.	0.598
EAR24215.1	EAR26147.1	A20C1_12244	A20C1_09709	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	Membrane protein.	0.435
EAR24215.1	lysS	A20C1_12244	A20C1_07943	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	lysyl-tRNA synthetase.	0.615
EAR24527.1	EAR24215.1	A20C1_12887	A20C1_12244	Exodeoxyribonuclease VII small subunit.	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	0.422
EAR24527.1	EAR24901.1	A20C1_12887	A20C1_06456	Exodeoxyribonuclease VII small subunit.	Hypothetical protein; COG1316 Transcriptional regulator.	0.718
EAR24527.1	EAR24995.1	A20C1_12887	A20C1_06926	Exodeoxyribonuclease VII small subunit.	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases.	0.453
EAR24527.1	EAR25615.1	A20C1_12887	A20C1_05091	Exodeoxyribonuclease VII small subunit.	Hypothetical protein.	0.683
EAR24576.1	EAR24901.1	A20C1_13132	A20C1_06456	COG5542 Predicted integral membrane protein.	Hypothetical protein; COG1316 Transcriptional regulator.	0.712
EAR24576.1	EAR25615.1	A20C1_13132	A20C1_05091	COG5542 Predicted integral membrane protein.	Hypothetical protein.	0.466
EAR24901.1	EAR24215.1	A20C1_06456	A20C1_12244	Hypothetical protein; COG1316 Transcriptional regulator.	ABC transporter, permease protein; COG0477 Permeases of the major facilitator superfamily.	0.661
EAR24901.1	EAR24527.1	A20C1_06456	A20C1_12887	Hypothetical protein; COG1316 Transcriptional regulator.	Exodeoxyribonuclease VII small subunit.	0.718
EAR24901.1	EAR24576.1	A20C1_06456	A20C1_13132	Hypothetical protein; COG1316 Transcriptional regulator.	COG5542 Predicted integral membrane protein.	0.712
EAR24901.1	EAR24902.1	A20C1_06456	A20C1_06461	Hypothetical protein; COG1316 Transcriptional regulator.	Hypothetical protein.	0.818
EAR24901.1	EAR24995.1	A20C1_06456	A20C1_06926	Hypothetical protein; COG1316 Transcriptional regulator.	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases.	0.642
EAR24901.1	EAR25084.1	A20C1_06456	A20C1_00811	Hypothetical protein; COG1316 Transcriptional regulator.	Membrane protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.	0.697
EAR24901.1	EAR25615.1	A20C1_06456	A20C1_05091	Hypothetical protein; COG1316 Transcriptional regulator.	Hypothetical protein.	0.744

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

11 of 22

2.47

10.23

1.05e-23

GO:0051085

Chaperone cofactor-dependent protein refolding

6 of 6

2.77

6.09

2.47e-12

GO:0009408

Response to heat

5 of 6

2.69

4.91

4.47e-10

GO:0042026

Protein refolding

4 of 5

2.68

3.79

7.58e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051082

Unfolded protein binding

10 of 14

2.63

10.25

3.83e-22

GO:0140662

ATP-dependent protein folding chaperone

8 of 11

2.63

8.12

4.48e-17

GO:0051087

Chaperone binding

3 of 3

2.77

3.04

2.44e-06

GO:0031072

Heat shock protein binding

2 of 2

2.77

1.83

0.00046

GO:0030554

Adenyl nucleotide binding

11 of 487

1.13

1.63

6.29e-11

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990220

GroEL-GroES complex

3 of 3

2.77

2.87

5.00e-06

GO:0005829

Cytosol

5 of 344

0.94

0.71

0.0035

GO:0005737

Cytoplasm

11 of 1358

0.68

0.64

4.68e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1148

Unfolded protein binding, and ClpA/B, conserved site 1

11 of 17

2.58

11.08

1.20e-24

CL:1151

Unfolded protein binding

10 of 12

2.69

10.81

5.90e-23

CL:1165

De novo post-translational protein folding

5 of 5

2.77

5.12

2.16e-10

CL:1153

Heat shock protein 70kD, peptide-binding domain superfamily, and Chaperone DnaJ, C-terminal

5 of 6

2.69

4.97

3.45e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pls03018

RNA degradation

5 of 20

2.17

3.61

2.79e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990220

GroEL-GroES complex

3 of 3

2.77

2.57

1.86e-05

GOCC:0005737

Cytoplasm

7 of 1060

0.59

0.38

0.0288

GOCC:0110165

Cellular anatomical entity

11 of 3202

0.31

0.25

0.0266

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

9 of 15

2.55

8.86

2.52e-19

KW-0346

Stress response

3 of 6

2.47

2.49

2.07e-05

KW-0963

Cytoplasm

7 of 234

1.25

1.53

2.60e-06

KW-0067

ATP-binding

5 of 300

0.99

0.74

0.0041

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00118

TCP-1/cpn60 chaperonin family

3 of 3

2.77

2.35

4.81e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037124

GroES chaperonin superfamily

3 of 3

2.77

2.14

0.00012

IPR027413

GroEL-like equatorial domain superfamily

3 of 3

2.77

2.14

0.00012

IPR027410

TCP-1-like chaperonin intermediate domain superfamily

3 of 3

2.77

2.14

0.00012

IPR027409

GroEL-like apical domain superfamily

3 of 3

2.77

2.14

0.00012

IPR020818

GroES chaperonin family

3 of 3

2.77

2.14

0.00012

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00883

Chaperonin 10 Kd subunit

3 of 3

2.77

2.74

8.93e-06

SM00271

DnaJ molecular chaperone homology domain

2 of 3

2.6

1.53

0.0016

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