STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EAR26216.1uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (250 aa)    
Predicted Functional Partners:
EAR26210.1
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.995
EAR26211.1
COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 0.985
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.943
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.826
hemL
COG0001 Glutamate-1-semialdehyde aminotransferase.
 
 
 0.754
EAR26207.1
COG1232 Protoporphyrinogen oxidase.
 
 
 0.702
EAR26213.1
Hypothetical protein.
 
     0.685
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.673
EAR24658.1
COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component.
 
    0.668
EAR26214.1
Hypothetical protein.
       0.639
Your Current Organism:
actinobacterium PHSC20C1
NCBI taxonomy Id: 312284
Other names: m. actinobacterium PHSC20C1, marine actinobacterium PHSC20C1, marine actinobacterium str. PHSC20C1, marine actinobacterium strain PHSC20C1
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