node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | gcvT | VF_1793 | VF_A0700 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | 0.952 |
fhs | metE | VF_1793 | VF_1721 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.577 |
fhs | metF | VF_1793 | VF_2309 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.842 |
fhs | metH | VF_1793 | VF_0337 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.947 |
gcvT | fhs | VF_A0700 | VF_1793 | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.952 |
gcvT | metF | VF_A0700 | VF_2309 | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.941 |
gcvT | metH | VF_A0700 | VF_0337 | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.952 |
luxS | metB | VF_0545 | VF_2267 | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Cystathionine gamma-synthase, PLP-dependent. | 0.963 |
luxS | metC | VF_0545 | VF_1186 | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Cystathionine beta-lyase, PLP-dependent. | 0.951 |
luxS | metE | VF_0545 | VF_1721 | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.971 |
luxS | metH | VF_0545 | VF_0337 | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.968 |
luxS | metK | VF_0545 | VF_0439 | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.700 |
luxS | metL | VF_0545 | VF_2266 | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Fused aspartokinase II/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.833 |
luxS | thrA | VF_0545 | VF_2118 | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Fused aspartokinase I and homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.886 |
metB | luxS | VF_2267 | VF_0545 | Cystathionine gamma-synthase, PLP-dependent. | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.963 |
metB | metC | VF_2267 | VF_1186 | Cystathionine gamma-synthase, PLP-dependent. | Cystathionine beta-lyase, PLP-dependent. | 0.922 |
metB | metE | VF_2267 | VF_1721 | Cystathionine gamma-synthase, PLP-dependent. | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.961 |
metB | metF | VF_2267 | VF_2309 | Cystathionine gamma-synthase, PLP-dependent. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.744 |
metB | metH | VF_2267 | VF_0337 | Cystathionine gamma-synthase, PLP-dependent. | homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.976 |
metB | metL | VF_2267 | VF_2266 | Cystathionine gamma-synthase, PLP-dependent. | Fused aspartokinase II/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.986 |