STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrfEHeme lyase (NrfEFG) for insertion of heme into c552, subunit NrfE. (628 aa)    
Predicted Functional Partners:
VF_1549
Thiol:disulfide interchange protein TlpA.
 
  
 0.979
nrfF
Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF; Possible subunit of a heme lyase.
  
 0.974
ccmG
Periplasmic thioredoxin of cytochrome c-type biogenesis.
 
  
 0.913
ccmI
Cytochrome c-type biogenesis protein CcmI.
 
 0.883
ccmE
Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 
 0.880
ccmH
Cytochrome c-type biogenesis protein CcmH; Possible subunit of a heme lyase.
  
 0.876
ccmC
Heme exporter subunit C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
  
 0.830
ccmB
Heme exporter subunit B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
  
 0.825
ccmA
Heme exporter subunit A; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
   
 0.802
nrfD
Formate-dependent nitrite reductase, membrane subunit.
 
    0.745
Your Current Organism:
Aliivibrio fischeri
NCBI taxonomy Id: 312309
Other names: A. fischeri ES114, Aliivibrio fischeri ES114, Vibrio fischeri ES114, Vibrio fischeri str. ES114, Vibrio fischeri strain ES114
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