Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aceBMalate synthase A; Belongs to the malate synthase family. (534 aa)    
Predicted Functional Partners:
aceA
Isocitrate lyase.
 
 0.999
gltA
Citrate synthase; Belongs to the citrate synthase family.
   
 0.987
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.978
acs
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.956
mdh
Malate dehydrogenase, NAD(P)-binding; Catalyzes the reversible oxidation of malate to oxaloacetate.
   
 0.929
fumB
Anaerobic class I fumarate hydratase (fumarase B); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
 0.926
VF_0339
Serine--pyruvate aminotransferase.
  
 
 0.910
adhE
Fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 
 0.908
maeA
Malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme); Belongs to the malic enzymes family.
    
 0.908
maeB
Fused malic enzyme predicted oxidoreductase/predicted phosphotransacetylase.
    
 0.908
Your Current Organism:
Aliivibrio fischeri
NCBI taxonomy Id: 312309
Other names: A. fischeri ES114, Aliivibrio fischeri ES114, Vibrio fischeri ES114, Vibrio fischeri str. ES114, Vibrio fischeri strain ES114
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