STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ahpCAlkyl hydroperoxide reductase, C22 subunit. (202 aa)    
Predicted Functional Partners:
VF_2300
Glutaredoxin.
  
 0.968
trxB
Thioredoxin reductase, FAD/NAD(P)-binding.
  
 
 0.950
VF_1549
Thiol:disulfide interchange protein TlpA.
  
 0.923
ccmG
Periplasmic thioredoxin of cytochrome c-type biogenesis.
  
 0.923
katA
Hydroperoxidase HPII(III) (catalase) KatA; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Could protect cells in nodules which have a high potential to produce hydrogen peroxide because of the strong reducing conditions required for nitrogen fixation and the action of several proteins; Belongs to the catalase family.
  
 
 0.828
grpE
Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]
   
 
 0.804
sodB
Superoxide dismutase, Fe; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.802
fur
DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport; Belongs to the Fur family.
  
  
 0.737
msrB
Methionine sulfoxide reductase B; Belongs to the MsrB Met sulfoxide reductase family.
     
 0.706
ftnA
Ferritin iron storage protein (cytoplasmic); Iron-storage protein.
  
  
 0.702
Your Current Organism:
Aliivibrio fischeri
NCBI taxonomy Id: 312309
Other names: A. fischeri ES114, Aliivibrio fischeri ES114, Vibrio fischeri ES114, Vibrio fischeri str. ES114, Vibrio fischeri strain ES114
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