node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRE_01039 | CRE_04614 | E3MI74 | E3LZF7 | Mcm10 domain-containing protein. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.976 |
CRE_01039 | CRE_13961 | E3MI74 | E3M8Z6 | Mcm10 domain-containing protein. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.951 |
CRE_01039 | Cre-cdc-6 | E3MI74 | E3MGJ8 | Mcm10 domain-containing protein. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.999 |
CRE_01039 | Cre-cdt-1 | E3MI74 | E3LM37 | Mcm10 domain-containing protein. | CRE-CDT-1 protein. | 0.998 |
CRE_01039 | Cre-mcm-2 | E3MI74 | E3N2S4 | Mcm10 domain-containing protein. | DNA helicase; Belongs to the MCM family. | 0.997 |
CRE_01039 | Cre-mcm-3 | E3MI74 | E3NCJ2 | Mcm10 domain-containing protein. | CRE-MCM-3 protein; Belongs to the MCM family. | 0.998 |
CRE_01039 | Cre-mcm-4 | E3MI74 | E3M3H8 | Mcm10 domain-containing protein. | DNA helicase; Belongs to the MCM family. | 0.999 |
CRE_01039 | Cre-mcm-5 | E3MI74 | E3ML13 | Mcm10 domain-containing protein. | DNA helicase; Belongs to the MCM family. | 0.998 |
CRE_01039 | Cre-mcm-6 | E3MI74 | E3LS69 | Mcm10 domain-containing protein. | DNA helicase; Belongs to the MCM family. | 0.999 |
CRE_01039 | MCM7 | E3MI74 | E3LKS8 | Mcm10 domain-containing protein. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.993 |
CRE_04614 | CRE_01039 | E3LZF7 | E3MI74 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | Mcm10 domain-containing protein. | 0.976 |
CRE_04614 | CRE_13961 | E3LZF7 | E3M8Z6 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.934 |
CRE_04614 | Cre-cdc-6 | E3LZF7 | E3MGJ8 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.999 |
CRE_04614 | Cre-cdt-1 | E3LZF7 | E3LM37 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | CRE-CDT-1 protein. | 0.999 |
CRE_04614 | Cre-mcm-2 | E3LZF7 | E3N2S4 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | DNA helicase; Belongs to the MCM family. | 0.999 |
CRE_04614 | Cre-mcm-3 | E3LZF7 | E3NCJ2 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | CRE-MCM-3 protein; Belongs to the MCM family. | 0.999 |
CRE_04614 | Cre-mcm-4 | E3LZF7 | E3M3H8 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | DNA helicase; Belongs to the MCM family. | 0.999 |
CRE_04614 | Cre-mcm-5 | E3LZF7 | E3ML13 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | DNA helicase; Belongs to the MCM family. | 0.999 |
CRE_04614 | Cre-mcm-6 | E3LZF7 | E3LS69 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | DNA helicase; Belongs to the MCM family. | 0.999 |
CRE_04614 | MCM7 | E3LZF7 | E3LKS8 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.993 |