Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
A0A183NJS0SP-RING-type domain-containing protein. (229 aa)    
Predicted Functional Partners:
A0A183PAJ8
Small ubiquitin-related modifier.
    
 0.979
SMTD_LOCUS9143
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.972
A0A183P7H7
ULP_PROTEASE domain-containing protein.
   
 
 0.863
A0A183PDU1
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.854
A0A183PMM5
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.814
SMTD_LOCUS1275
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
  0.760
SMTD_LOCUS3126
AGC-kinase C-terminal domain-containing protein.
    
  0.760
A0A183PRM6
Phorbol-ester/DAG-type domain-containing protein.
    
  0.760
A0A183Q0W2
PB1 domain-containing protein.
    
  0.760
A0A183Q3S5
RECA_2 domain-containing protein.
    
 
 0.738
Your Current Organism:
Schistosoma mattheei
NCBI taxonomy Id: 31246
Other names: S. mattheei
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