JNB_04475 protein (Janibacter sp. HTCC2649) - STRING interaction network

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Score

JNB_04475

Putative secreted protease; COG4412 Uncharacterized protein conserved in bacteria. (759 aa)

Predicted Functional Partners:

JNB_17093

0.603

JNB_04470

0.550

glnE

0.510

hisC

0.502

hisD

0.502

hisH

0.499

panB

0.498

JNB_04445

0.497

hisB

0.497

JNB_17478

0.462

Your Current Organism:

Janibacter sp. HTCC2649

NCBI taxonomy Id: 313589
Other names: J. sp. HTCC2649

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JNB_04445	JNB_04470	JNB_04445	JNB_04470	Hypothetical protein.	COG0174 Glutamine synthetase.	0.753
JNB_04445	JNB_04475	JNB_04445	JNB_04475	Hypothetical protein.	Putative secreted protease; COG4412 Uncharacterized protein conserved in bacteria.	0.497
JNB_04445	glnE	JNB_04445	JNB_04465	Hypothetical protein.	Putative glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the sign [...]	0.787
JNB_04445	hisB	JNB_04445	JNB_04450	Hypothetical protein.	COG0131 Imidazoleglycerol-phosphate dehydratase.	0.802
JNB_04445	hisC	JNB_04445	JNB_04455	Hypothetical protein.	COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.992
JNB_04445	hisD	JNB_04445	JNB_04460	Hypothetical protein.	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.991
JNB_04445	hisH	JNB_04445	JNB_04440	Hypothetical protein.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.992
JNB_04470	JNB_04445	JNB_04470	JNB_04445	COG0174 Glutamine synthetase.	Hypothetical protein.	0.753
JNB_04470	JNB_04475	JNB_04470	JNB_04475	COG0174 Glutamine synthetase.	Putative secreted protease; COG4412 Uncharacterized protein conserved in bacteria.	0.550
JNB_04470	glnE	JNB_04470	JNB_04465	COG0174 Glutamine synthetase.	Putative glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the sign [...]	0.932
JNB_04470	hisB	JNB_04470	JNB_04450	COG0174 Glutamine synthetase.	COG0131 Imidazoleglycerol-phosphate dehydratase.	0.753
JNB_04470	hisC	JNB_04470	JNB_04455	COG0174 Glutamine synthetase.	COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.757
JNB_04470	hisD	JNB_04470	JNB_04460	COG0174 Glutamine synthetase.	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.777
JNB_04470	hisH	JNB_04470	JNB_04440	COG0174 Glutamine synthetase.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.887
JNB_04470	panB	JNB_04470	JNB_04480	COG0174 Glutamine synthetase.	3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.	0.549
JNB_04475	JNB_04445	JNB_04475	JNB_04445	Putative secreted protease; COG4412 Uncharacterized protein conserved in bacteria.	Hypothetical protein.	0.497
JNB_04475	JNB_04470	JNB_04475	JNB_04470	Putative secreted protease; COG4412 Uncharacterized protein conserved in bacteria.	COG0174 Glutamine synthetase.	0.550
JNB_04475	JNB_17093	JNB_04475	JNB_17093	Putative secreted protease; COG4412 Uncharacterized protein conserved in bacteria.	Hypothetical protein; COG0346 Lactoylglutathione lyase and related lyases.	0.603
JNB_04475	JNB_17478	JNB_04475	JNB_17478	Putative secreted protease; COG4412 Uncharacterized protein conserved in bacteria.	Hypothetical protein.	0.462
JNB_04475	glnE	JNB_04475	JNB_04465	Putative secreted protease; COG4412 Uncharacterized protein conserved in bacteria.	Putative glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the sign [...]	0.510