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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JNB_08604COG0500 SAM-dependent methyltransferases. (221 aa)    
Predicted Functional Partners:
JNB_08599
Hypothetical protein; COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component.
       0.774
JNB_06949
Putative oxidoreductase protein; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
   
  0.728
JNB_19333
Putative dehydrogenase protein; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
   
  0.728
JNB_20148
COG1239 Mg-chelatase subunit ChlI.
  
 0.719
JNB_08614
Putative short chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
   0.703
JNB_11319
Hypothetical protein; COG4639 Predicted kinase.
   
   0.689
JNB_08609
Beta-lactamase related protein; COG2367 Beta-lactamase class A.
       0.678
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
  0.666
JNB_08594
Hypothetical protein.
       0.548
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
  0.479
Your Current Organism:
Janibacter sp. HTCC2649
NCBI taxonomy Id: 313589
Other names: J. sp. HTCC2649
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