JNB_13643 protein (Janibacter sp. HTCC2649) - STRING interaction network

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JNB_13643

Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase. (304 aa)

Predicted Functional Partners:

JNB_15533

0.925

JNB_18078

0.925

JNB_19213

0.925

nth

0.800

disA

0.796

JNB_13648

0.782

recO

0.745

mutM

0.744

radA

0.704

uvrB

0.676

Your Current Organism:

Janibacter sp. HTCC2649

NCBI taxonomy Id: 313589
Other names: J. sp. HTCC2649

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JNB_13643	JNB_13648	JNB_13643	JNB_13648	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	Putative integral membrane protein.	0.782
JNB_13643	JNB_15533	JNB_13643	JNB_15533	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	AP endonuclease, family 1:Exodeoxyribonuclease III xth; COG0708 Exonuclease III.	0.925
JNB_13643	JNB_18078	JNB_13643	JNB_18078	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	COG0708 Exonuclease III.	0.925
JNB_13643	JNB_19213	JNB_13643	JNB_19213	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	Hypothetical protein.	0.925
JNB_13643	disA	JNB_13643	JNB_13638	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	Putative DNA-binding protein; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.	0.796
JNB_13643	mutM	JNB_13643	JNB_19588	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.744
JNB_13643	nth	JNB_13643	JNB_10059	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	Putative endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.800
JNB_13643	radA	JNB_13643	JNB_13633	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	Putative DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	0.704
JNB_13643	recO	JNB_13643	JNB_04850	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.745
JNB_13643	uvrB	JNB_13643	JNB_03615	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]	0.676
JNB_13648	JNB_13643	JNB_13648	JNB_13643	Putative integral membrane protein.	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	0.782
JNB_13648	disA	JNB_13648	JNB_13638	Putative integral membrane protein.	Putative DNA-binding protein; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.	0.733
JNB_13648	radA	JNB_13648	JNB_13633	Putative integral membrane protein.	Putative DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	0.465
JNB_15533	JNB_13643	JNB_15533	JNB_13643	AP endonuclease, family 1:Exodeoxyribonuclease III xth; COG0708 Exonuclease III.	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	0.925
JNB_15533	JNB_18078	JNB_15533	JNB_18078	AP endonuclease, family 1:Exodeoxyribonuclease III xth; COG0708 Exonuclease III.	COG0708 Exonuclease III.	0.900
JNB_15533	nth	JNB_15533	JNB_10059	AP endonuclease, family 1:Exodeoxyribonuclease III xth; COG0708 Exonuclease III.	Putative endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.895
JNB_18078	JNB_13643	JNB_18078	JNB_13643	COG0708 Exonuclease III.	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	0.925
JNB_18078	JNB_15533	JNB_18078	JNB_15533	COG0708 Exonuclease III.	AP endonuclease, family 1:Exodeoxyribonuclease III xth; COG0708 Exonuclease III.	0.900
JNB_18078	nth	JNB_18078	JNB_10059	COG0708 Exonuclease III.	Putative endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.988
JNB_19213	JNB_13643	JNB_19213	JNB_13643	Hypothetical protein.	Putative adenine glycosylase; COG1194 A/G-specific DNA glycosylase.	0.925