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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JNB_16664DNA ligase; COG1793 ATP-dependent DNA ligase. (112 aa)    
Predicted Functional Partners:
JNB_13403
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.989
polA
Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.856
JNB_02670
Putative exonuclease; COG0419 ATPase involved in DNA repair.
   
 0.836
sbcD
Putative exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.799
JNB_13738
DNA ligase; COG3285 Predicted eukaryotic-type DNA primase.
 
  
 0.798
ku
Hypothetical protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.791
JNB_16679
COG1061 DNA or RNA helicases of superfamily II.
  
 
  0.778
JNB_17683
Hypothetical protein; COG3285 Predicted eukaryotic-type DNA primase.
 
  
 0.777
JNB_02890
COG0258 5'-3' exonuclease (including N-terminal domain of PolI).
   
 0.765
JNB_05115
Putative ATP-dependent helicase; COG1199 Rad3-related DNA helicases.
   
 
 0.763
Your Current Organism:
Janibacter sp. HTCC2649
NCBI taxonomy Id: 313589
Other names: J. sp. HTCC2649
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