Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (619 aa)    
Predicted Functional Partners:
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.982
EAR11900.1
COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 
 0.981
EAR11897.1
COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
 
  
 0.980
EAR12579.1
COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 
 0.972
thiE-2
Thiamine monophosphate syntase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.953
EAR11903.1
COG2104 Sulfur transfer protein involved in thiamine biosynthesis.
  
  
 0.951
EAR11901.1
COG0352 Thiamine monophosphate synthase.
 
 
 0.901
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.884
EAR11896.1
COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
 
  
 0.881
EAR12917.1
Thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase.
  
 
 0.763
Your Current Organism:
Polaribacter irgensii
NCBI taxonomy Id: 313594
Other names: P. irgensii 23-P, Polaribacter irgensii 23-P
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