AFU70259.1 protein (Psychroflexus torquis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AFU70259.1

Peroxiredoxin, 1-cys family AhpC. (210 aa)

Predicted Functional Partners:

AFU67553.1

0.578

AFU70258.1

0.553

AFU67477.1

0.552

AFU69103.1

0.552

AFU69774.1

0.552

AFU67544.1

0.477

AFU67628.1

0.477

AFU69005.1

0.477

AFU69628.1

0.477

AFU69725.1

0.477

Your Current Organism:

Psychroflexus torquis

NCBI taxonomy Id: 313595
Other names: P. torquis ATCC 700755, Psychroflexus torquis ACAM 623, Psychroflexus torquis ATCC 700755, Psychroflexus torquis str. ATCC 700755, Psychroflexus torquis strain ATCC 700755

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFU67477.1	AFU69103.1	P700755_000454	P700755_002324	Thioredoxin disulfide reductase TrxB.	Thioredoxin reductase TrxB.	0.907
AFU67477.1	AFU69628.1	P700755_000454	P700755_002925	Thioredoxin disulfide reductase TrxB.	Protein disulfide isomerase (thioredoxin), TRX family.	0.423
AFU67477.1	AFU69774.1	P700755_000454	P700755_003104	Thioredoxin disulfide reductase TrxB.	Bacillithiol system oxidoreductase, YpdA family.	0.900
AFU67477.1	AFU70259.1	P700755_000454	P700755_003669	Thioredoxin disulfide reductase TrxB.	Peroxiredoxin, 1-cys family AhpC.	0.552
AFU67544.1	AFU70259.1	P700755_000521	P700755_003669	Thioredoxin disulfide isomerase, putative.	Peroxiredoxin, 1-cys family AhpC.	0.477
AFU67553.1	AFU70259.1	P700755_000530	P700755_003669	Ferric uptake regulation protein Fur; Belongs to the Fur family.	Peroxiredoxin, 1-cys family AhpC.	0.578
AFU67628.1	AFU70259.1	P700755_000608	P700755_003669	Protein with tryparedoxin/glycerophosphodiester phosphodiesterase domains.	Peroxiredoxin, 1-cys family AhpC.	0.477
AFU69005.1	AFU69103.1	P700755_002215	P700755_002324	DNA-3-methyladenine glycosylase Tag.	Thioredoxin reductase TrxB.	0.449
AFU69005.1	AFU70259.1	P700755_002215	P700755_003669	DNA-3-methyladenine glycosylase Tag.	Peroxiredoxin, 1-cys family AhpC.	0.477
AFU69103.1	AFU67477.1	P700755_002324	P700755_000454	Thioredoxin reductase TrxB.	Thioredoxin disulfide reductase TrxB.	0.907
AFU69103.1	AFU69005.1	P700755_002324	P700755_002215	Thioredoxin reductase TrxB.	DNA-3-methyladenine glycosylase Tag.	0.449
AFU69103.1	AFU69774.1	P700755_002324	P700755_003104	Thioredoxin reductase TrxB.	Bacillithiol system oxidoreductase, YpdA family.	0.900
AFU69103.1	AFU70259.1	P700755_002324	P700755_003669	Thioredoxin reductase TrxB.	Peroxiredoxin, 1-cys family AhpC.	0.552
AFU69628.1	AFU67477.1	P700755_002925	P700755_000454	Protein disulfide isomerase (thioredoxin), TRX family.	Thioredoxin disulfide reductase TrxB.	0.423
AFU69628.1	AFU70259.1	P700755_002925	P700755_003669	Protein disulfide isomerase (thioredoxin), TRX family.	Peroxiredoxin, 1-cys family AhpC.	0.477
AFU69725.1	AFU70259.1	P700755_003055	P700755_003669	Thiol:disulfide interchange protein, TlpA_like family.	Peroxiredoxin, 1-cys family AhpC.	0.477
AFU69774.1	AFU67477.1	P700755_003104	P700755_000454	Bacillithiol system oxidoreductase, YpdA family.	Thioredoxin disulfide reductase TrxB.	0.900
AFU69774.1	AFU69103.1	P700755_003104	P700755_002324	Bacillithiol system oxidoreductase, YpdA family.	Thioredoxin reductase TrxB.	0.900
AFU69774.1	AFU70259.1	P700755_003104	P700755_003669	Bacillithiol system oxidoreductase, YpdA family.	Peroxiredoxin, 1-cys family AhpC.	0.552
AFU70258.1	AFU70259.1	P700755_003668	P700755_003669	Hypothetical protein.	Peroxiredoxin, 1-cys family AhpC.	0.553

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.778

expected number of edges:

11

PPI enrichment p-value:

9.49e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

6 of 70

1.66

2.34

1.05e-06

GO:0006091

Generation of precursor metabolites and energy

7 of 115

1.51

2.14

5.39e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

5 of 19

2.15

3.2

2.41e-07

GO:0005506

Iron ion binding

4 of 27

1.9

2.04

4.95e-05

GO:0030976

Thiamine pyrophosphate binding

3 of 9

2.25

1.98

0.00016

GO:0016491

Oxidoreductase activity

8 of 243

1.25

1.61

5.31e-07

GO:0051539

4 iron, 4 sulfur cluster binding

5 of 88

1.48

1.6

6.95e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1147

Pyruvate:ferredoxin oxidoreductase core domain II, and Dicarboxylic acid catabolic process

5 of 5

2.73

4.71

1.25e-09

CL:1143

Citrate cycle (TCA cycle), and L-lactate dehydrogenase

6 of 21

2.18

4.17

1.25e-09

CL:1135

Mixed, incl. Generation of precursor metabolites and energy, and Pyruvate metabolism

10 of 131

1.61

3.44

6.20e-13

CL:1136

Mixed, incl. Generation of precursor metabolites and energy, and Pyruvate metabolism

8 of 118

1.56

2.73

1.76e-09

CL:1340

Mixed, incl. Formate dehydrogenase complex, and NADH dehydrogenase

2 of 6

2.25

1.09

0.0094

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

7 of 18

2.32

5.79

3.83e-13

map00650

Butanoate metabolism

6 of 21

2.18

4.58

1.07e-10

map00010

Glycolysis / Gluconeogenesis

6 of 46

1.84

3.34

4.66e-09

map00620

Pyruvate metabolism

6 of 53

1.78

3.14

8.21e-09

map01200

Carbon metabolism

8 of 102

1.62

3.13

1.07e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

3 of 43

1.57

0.82

0.0208

GOCC:0045272

Plasma membrane respiratory chain complex I

2 of 11

1.99

0.77

0.0360

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

5 of 27

2.0

2.98

3.25e-07

KW-0560

Oxidoreductase

6 of 129

1.4

1.73

5.76e-06

KW-0249

Electron transport

2 of 6

2.25

1.18

0.0062

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

5 of 5

2.73

4.67

1.50e-09

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

3 of 3

2.73

2.41

3.69e-05

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

3 of 5

2.51

2.29

5.15e-05

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

3 of 7

2.36

2.14

8.81e-05

PF00037

4Fe-4S binding domain

4 of 24

1.95

2.13

3.69e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019752

Pyruvate/ketoisovalerate oxidoreductase, catalytic domain

5 of 5

2.73

4.47

3.70e-09

IPR002869

Pyruvate-flavodoxin oxidoreductase, central domain

5 of 5

2.73

4.47

3.70e-09

IPR029061

Thiamin diphosphate-binding fold

4 of 12

2.25

2.62

7.43e-06

IPR033412

Pyruvate:ferredoxin oxidoreductase, core domain II

3 of 3

2.73

2.41

3.63e-05

IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

3 of 5

2.51

2.18

8.46e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00890

Domain of unknown function

2 of 2

2.73

1.37

0.0032

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (12%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About