STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EAR14062.1Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (583 aa)    
Predicted Functional Partners:
EAR15530.1
Putative acetolactate synthase large subunit.
  
 0.907
EAR17100.1
Glutamate synthase (ferredoxin).
  
  
 0.811
EAR15531.1
Putative acetohydroxyacid synthase small subunit.
 
 
 0.801
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
  
 0.794
leuC
Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.774
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.771
EAR16846.1
Putative threonine dehydratase, catabolic.
 
  
 0.743
EAR15536.1
Putative 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.734
EAR14061.1
GntP family permease.
  
  
 0.717
EAR14059.1
Hypothetical protein.
  
    0.685
Your Current Organism:
Robiginitalea biformata
NCBI taxonomy Id: 313596
Other names: R. biformata HTCC2501, Robiginitalea biformata HTCC2501, Robiginitalea biformata str. HTCC2501, Robiginitalea biformata strain HTCC2501
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.