| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR14380.1 | EAR14388.1 | RB2501_03110 | RB2501_03150 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional aspartokinase I/homeserine dehydrogenase I. | 0.994 |
| EAR14380.1 | EAR15234.1 | RB2501_03110 | RB2501_12939 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Threonine synthase. | 0.454 |
| EAR14380.1 | EAR15236.1 | RB2501_03110 | RB2501_12949 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartokinase/homoserine dehydrogenase. | 0.963 |
| EAR14380.1 | EAR15403.1 | RB2501_03110 | RB2501_13784 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase. | 0.965 |
| EAR14380.1 | EAR16783.1 | RB2501_03110 | RB2501_07775 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cys/Met metabolism PLP-dependent enzyme superfamily protein. | 0.965 |
| EAR14380.1 | metZ | RB2501_03110 | RB2501_03145 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.971 |
| EAR14380.1 | thrB | RB2501_03110 | RB2501_12944 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.879 |
| EAR14388.1 | EAR14380.1 | RB2501_03150 | RB2501_03110 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.994 |
| EAR14388.1 | EAR14882.1 | RB2501_03150 | RB2501_11167 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.928 |
| EAR14388.1 | EAR15234.1 | RB2501_03150 | RB2501_12939 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | Threonine synthase. | 0.980 |
| EAR14388.1 | EAR15236.1 | RB2501_03150 | RB2501_12949 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | Aspartokinase/homoserine dehydrogenase. | 0.991 |
| EAR14388.1 | EAR15373.1 | RB2501_03150 | RB2501_13634 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | 4-amino-4-deoxychorismate lyase, putative. | 0.928 |
| EAR14388.1 | EAR15403.1 | RB2501_03150 | RB2501_13784 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | Cystathionine beta-lyase. | 0.939 |
| EAR14388.1 | EAR15801.1 | RB2501_03150 | RB2501_15774 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.848 |
| EAR14388.1 | EAR16783.1 | RB2501_03150 | RB2501_07775 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | Cys/Met metabolism PLP-dependent enzyme superfamily protein. | 0.939 |
| EAR14388.1 | metZ | RB2501_03150 | RB2501_03145 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.980 |
| EAR14388.1 | thrB | RB2501_03150 | RB2501_12944 | Bifunctional aspartokinase I/homeserine dehydrogenase I. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.998 |
| EAR14882.1 | EAR14388.1 | RB2501_11167 | RB2501_03150 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Bifunctional aspartokinase I/homeserine dehydrogenase I. | 0.928 |
| EAR14882.1 | EAR15236.1 | RB2501_11167 | RB2501_12949 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Aspartokinase/homoserine dehydrogenase. | 0.912 |
| EAR14882.1 | EAR15373.1 | RB2501_11167 | RB2501_13634 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 4-amino-4-deoxychorismate lyase, putative. | 0.900 |