node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAQ99841.1 | EAR01866.1 | FB2170_16006 | FB2170_15098 | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | 0.691 |
EAQ99841.1 | clpB | FB2170_16006 | FB2170_13261 | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | Putative heat shock ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.674 |
EAQ99841.1 | dnaK | FB2170_16006 | FB2170_12941 | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
EAQ99841.1 | groL | FB2170_16006 | FB2170_08589 | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.837 |
EAQ99841.1 | groS | FB2170_16006 | FB2170_08594 | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.787 |
EAQ99841.1 | grpE | FB2170_16006 | FB2170_01140 | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | GrpE protein (Hsp-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.773 |
EAR00551.1 | groL | FB2170_08599 | FB2170_08589 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.526 |
EAR00551.1 | groS | FB2170_08599 | FB2170_08594 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.652 |
EAR01866.1 | EAQ99841.1 | FB2170_15098 | FB2170_16006 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.691 |
EAR01866.1 | clpP | FB2170_15098 | FB2170_02780 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit 2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.831 |
EAR01866.1 | dnaK | FB2170_15098 | FB2170_12941 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.915 |
EAR01866.1 | groL | FB2170_15098 | FB2170_08589 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.655 |
EAR01866.1 | groS | FB2170_15098 | FB2170_08594 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.638 |
EAR01866.1 | grpE | FB2170_15098 | FB2170_01140 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | GrpE protein (Hsp-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.784 |
acpP | groL | FB2170_06560 | FB2170_08589 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.432 |
acpP | groS | FB2170_06560 | FB2170_08594 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.682 |
acpP | rplL | FB2170_06560 | FB2170_16186 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Putative 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. | 0.871 |
clpB | EAQ99841.1 | FB2170_13261 | FB2170_16006 | Putative heat shock ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.674 |
clpB | clpP | FB2170_13261 | FB2170_02780 | Putative heat shock ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit 2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.825 |
clpB | dnaK | FB2170_13261 | FB2170_12941 | Putative heat shock ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.931 |