node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NSP_11580 | NSP_18030 | NSP_11580 | NSP_18030 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | YbbL ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. | 0.893 |
NSP_11580 | NSP_26720 | NSP_11580 | NSP_26720 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Malonyl CoA-acyl carrier protein transacylase; Nsp26720; ORF_ID:nsp26720. | 0.893 |
NSP_11580 | NSP_28610 | NSP_11580 | NSP_28610 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. | 0.895 |
NSP_11580 | NSP_35820 | NSP_11580 | NSP_35820 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase; Nsp35820; ORF_ID:nsp35820. | 0.929 |
NSP_11580 | NSP_46620 | NSP_11580 | NSP_46620 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein; Nsp46620; ORF_ID:nsp46620. | 0.937 |
NSP_11580 | NSP_50740 | NSP_11580 | NSP_50740 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase; Nsp50740; ORF_ID:nsp50740; Belongs to the methylenetetrahydrofolate reductase family. | 0.999 |
NSP_11580 | NSP_8770 | NSP_11580 | NSP_8770 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartokinase; Nsp8770; ORF_ID:nsp8770. | 0.895 |
NSP_11580 | ahcY | NSP_11580 | NSP_38970 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.940 |
NSP_11580 | gcvT | NSP_11580 | NSP_33150 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.946 |
NSP_11580 | metK | NSP_11580 | NSP_35770 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.940 |
NSP_18030 | NSP_11580 | NSP_18030 | NSP_11580 | YbbL ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.893 |
NSP_18030 | NSP_35820 | NSP_18030 | NSP_35820 | YbbL ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. | Homoserine dehydrogenase; Nsp35820; ORF_ID:nsp35820. | 0.661 |
NSP_18030 | NSP_50740 | NSP_18030 | NSP_50740 | YbbL ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. | 5,10-methylenetetrahydrofolate reductase; Nsp50740; ORF_ID:nsp50740; Belongs to the methylenetetrahydrofolate reductase family. | 0.907 |
NSP_18030 | ahcY | NSP_18030 | NSP_38970 | YbbL ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.579 |
NSP_18030 | metK | NSP_18030 | NSP_35770 | YbbL ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.733 |
NSP_26720 | NSP_11580 | NSP_26720 | NSP_11580 | Malonyl CoA-acyl carrier protein transacylase; Nsp26720; ORF_ID:nsp26720. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.893 |
NSP_26720 | NSP_28610 | NSP_26720 | NSP_28610 | Malonyl CoA-acyl carrier protein transacylase; Nsp26720; ORF_ID:nsp26720. | Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. | 0.937 |
NSP_26720 | NSP_8770 | NSP_26720 | NSP_8770 | Malonyl CoA-acyl carrier protein transacylase; Nsp26720; ORF_ID:nsp26720. | Aspartokinase; Nsp8770; ORF_ID:nsp8770. | 0.477 |
NSP_26720 | ahcY | NSP_26720 | NSP_38970 | Malonyl CoA-acyl carrier protein transacylase; Nsp26720; ORF_ID:nsp26720. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.550 |
NSP_26720 | gcvT | NSP_26720 | NSP_33150 | Malonyl CoA-acyl carrier protein transacylase; Nsp26720; ORF_ID:nsp26720. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.811 |