STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NSP_1450Acetolactate synthase large subunit; Nsp1450; ORF_ID:nsp1450. (632 aa)    
Predicted Functional Partners:
NSP_20200
Acetolactate synthase small subunit; Nsp20200; ORF_ID:nsp20200.
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.988
NSP_49310
3-isopropylmalate dehydratase large subunit; Nsp49310; ORF_ID:nsp49310; Belongs to the aconitase/IPM isomerase family.
 
 
 0.985
ilvD
Dihydroxy-acid dehydratase; Nsp33730; ORF_ID:nsp33730; Belongs to the IlvD/Edd family.
 
 0.972
NSP_28610
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.
  
 
 0.906
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
 0.885
NSP_15330
NADP-dependent malic enzyme; Nsp15330; ORF_ID:nsp15330.
  
 
 0.865
NSP_1710
Pyruvate kinase; Nsp1710; ORF_ID:nsp1710; Belongs to the pyruvate kinase family.
  
 0.853
NSP_49300
3-isopropylmalate dehydrogenase; Nsp49300; ORF_ID:nsp49300.
 0.853
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.845
Your Current Organism:
Nodularia spumigena
NCBI taxonomy Id: 313624
Other names: N. spumigena CCY9414, Nodularia spumigena CCY9414
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