NSP_18810 protein (Nodularia spumigena) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

NSP_18810

Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810. (280 aa)

Predicted Functional Partners:

NSP_42150

0.886

NSP_26720

0.850

NSP_42160

0.824

NSP_26730

0.752

NSP_8410

0.679

NSP_26950

0.677

NSP_26940

0.636

NSP_26710

0.631

NSP_52640

0.584

NSP_33580

0.569

Your Current Organism:

Nodularia spumigena

NCBI taxonomy Id: 313624
Other names: N. spumigena CCY9414, Nodularia spumigena CCY9414

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
NSP_18810	NSP_26710	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	0.631
NSP_18810	NSP_26720	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Malonyl CoA-acyl carrier protein transacylase; Nsp26720; ORF_ID:nsp26720.	0.850
NSP_18810	NSP_26730	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Long-chain-fatty-acid--CoA ligase; Nsp26730; ORF_ID:nsp26730.	0.752
NSP_18810	NSP_26940	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Malonyl CoA-acyl carrier protein transacylase; Nsp26940; ORF_ID:nsp26940.	0.636
NSP_18810	NSP_26950	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Long-chain-fatty-acid--CoA ligase; Nsp26950; ORF_ID:nsp26950.	0.677
NSP_18810	NSP_33580	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Phospholipid/glycerol acyltransferase; Nsp33580; ORF_ID:nsp33580.	0.569
NSP_18810	NSP_42150	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Malonyl CoA-acyl carrier protein transacylase; Nsp42150; ORF_ID:nsp42150.	0.886
NSP_18810	NSP_42160	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Malonyl CoA-acyl carrier protein transacylase; Nsp42160; ORF_ID:nsp42160.	0.824
NSP_18810	NSP_52640	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Signal transduction histidine kinase; Nsp52640; ORF_ID:nsp52640.	0.584
NSP_18810	NSP_8410	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	Lipase family protein, sll1969-like protein; Nsp8410; ORF_ID:nsp8410.	0.679
NSP_26710	NSP_18810	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Acyltransferase family protein; Nsp18810; ORF_ID:nsp18810.	0.631
NSP_26710	NSP_26720	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Malonyl CoA-acyl carrier protein transacylase; Nsp26720; ORF_ID:nsp26720.	0.999
NSP_26710	NSP_26730	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Long-chain-fatty-acid--CoA ligase; Nsp26730; ORF_ID:nsp26730.	0.999
NSP_26710	NSP_26940	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Malonyl CoA-acyl carrier protein transacylase; Nsp26940; ORF_ID:nsp26940.	0.995
NSP_26710	NSP_26950	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Long-chain-fatty-acid--CoA ligase; Nsp26950; ORF_ID:nsp26950.	0.998
NSP_26710	NSP_33580	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Phospholipid/glycerol acyltransferase; Nsp33580; ORF_ID:nsp33580.	0.631
NSP_26710	NSP_42150	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Malonyl CoA-acyl carrier protein transacylase; Nsp42150; ORF_ID:nsp42150.	0.999
NSP_26710	NSP_42160	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Malonyl CoA-acyl carrier protein transacylase; Nsp42160; ORF_ID:nsp42160.	0.999
NSP_26710	NSP_52640	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Signal transduction histidine kinase; Nsp52640; ORF_ID:nsp52640.	0.604
NSP_26710	NSP_8410	Malonyl CoA-acyl carrier protein transacylase; Nsp26710; ORF_ID:nsp26710.	Lipase family protein, sll1969-like protein; Nsp8410; ORF_ID:nsp8410.	0.558

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.778

expected number of edges:

11

PPI enrichment p-value:

9.49e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

6 of 70

1.66

2.34

1.05e-06

GO:0006091

Generation of precursor metabolites and energy

7 of 115

1.51

2.14

5.39e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

5 of 19

2.15

3.2

2.41e-07

GO:0005506

Iron ion binding

4 of 27

1.9

2.04

4.95e-05

GO:0030976

Thiamine pyrophosphate binding

3 of 9

2.25

1.98

0.00016

GO:0016491

Oxidoreductase activity

8 of 243

1.25

1.61

5.31e-07

GO:0051539

4 iron, 4 sulfur cluster binding

5 of 88

1.48

1.6

6.95e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1147

Pyruvate:ferredoxin oxidoreductase core domain II, and Dicarboxylic acid catabolic process

5 of 5

2.73

4.71

1.25e-09

CL:1143

Citrate cycle (TCA cycle), and L-lactate dehydrogenase

6 of 21

2.18

4.17

1.25e-09

CL:1135

Mixed, incl. Generation of precursor metabolites and energy, and Pyruvate metabolism

10 of 131

1.61

3.44

6.20e-13

CL:1136

Mixed, incl. Generation of precursor metabolites and energy, and Pyruvate metabolism

8 of 118

1.56

2.73

1.76e-09

CL:1340

Mixed, incl. Formate dehydrogenase complex, and NADH dehydrogenase

2 of 6

2.25

1.09

0.0094

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

7 of 18

2.32

5.79

3.83e-13

map00650

Butanoate metabolism

6 of 21

2.18

4.58

1.07e-10

map00010

Glycolysis / Gluconeogenesis

6 of 46

1.84

3.34

4.66e-09

map00620

Pyruvate metabolism

6 of 53

1.78

3.14

8.21e-09

map01200

Carbon metabolism

8 of 102

1.62

3.13

1.07e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

3 of 43

1.57

0.82

0.0208

GOCC:0045272

Plasma membrane respiratory chain complex I

2 of 11

1.99

0.77

0.0360

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

5 of 27

2.0

2.98

3.25e-07

KW-0560

Oxidoreductase

6 of 129

1.4

1.73

5.76e-06

KW-0249

Electron transport

2 of 6

2.25

1.18

0.0062

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

5 of 5

2.73

4.67

1.50e-09

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

3 of 3

2.73

2.41

3.69e-05

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

3 of 5

2.51

2.29

5.15e-05

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

3 of 7

2.36

2.14

8.81e-05

PF00037

4Fe-4S binding domain

4 of 24

1.95

2.13

3.69e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019752

Pyruvate/ketoisovalerate oxidoreductase, catalytic domain

5 of 5

2.73

4.47

3.70e-09

IPR002869

Pyruvate-flavodoxin oxidoreductase, central domain

5 of 5

2.73

4.47

3.70e-09

IPR029061

Thiamin diphosphate-binding fold

4 of 12

2.25

2.62

7.43e-06

IPR033412

Pyruvate:ferredoxin oxidoreductase, core domain II

3 of 3

2.73

2.41

3.63e-05

IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

3 of 5

2.51

2.18

8.46e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00890

Domain of unknown function

2 of 2

2.73

1.37

0.0032

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