node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NSP_10130 | NSP_11580 | NSP_10130 | NSP_11580 | Ribulose-5-phosphate 4-epimerase; Nsp10130; ORF_ID:nsp10130. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.598 |
NSP_10130 | NSP_38210 | NSP_10130 | NSP_38210 | Ribulose-5-phosphate 4-epimerase; Nsp10130; ORF_ID:nsp10130. | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.913 |
NSP_10130 | cbbL | NSP_10130 | NSP_26260 | Ribulose-5-phosphate 4-epimerase; Nsp10130; ORF_ID:nsp10130. | Ribulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. | 0.875 |
NSP_10130 | mtnA | NSP_10130 | NSP_7920 | Ribulose-5-phosphate 4-epimerase; Nsp10130; ORF_ID:nsp10130. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.823 |
NSP_11580 | NSP_10130 | NSP_11580 | NSP_10130 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ribulose-5-phosphate 4-epimerase; Nsp10130; ORF_ID:nsp10130. | 0.598 |
NSP_11580 | NSP_30760 | NSP_11580 | NSP_30760 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate aminotransferase; Nsp30760; ORF_ID:nsp30760. | 0.821 |
NSP_11580 | NSP_33480 | NSP_11580 | NSP_33480 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | N-succinyl-L,L-diaminopimelate aminotransferase alternative; Nsp33480; ORF_ID:nsp33480. | 0.821 |
NSP_11580 | NSP_38210 | NSP_11580 | NSP_38210 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.716 |
NSP_11580 | NSP_39140 | NSP_11580 | NSP_39140 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate aminotransferase; Nsp39140; ORF_ID:nsp39140. | 0.821 |
NSP_11580 | NSP_50740 | NSP_11580 | NSP_50740 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase; Nsp50740; ORF_ID:nsp50740; Belongs to the methylenetetrahydrofolate reductase family. | 0.999 |
NSP_11580 | cbbL | NSP_11580 | NSP_26260 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ribulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. | 0.696 |
NSP_11580 | dapL | NSP_11580 | NSP_21120 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | L,L-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. | 0.821 |
NSP_11580 | mtnA | NSP_11580 | NSP_7920 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.840 |
NSP_30760 | NSP_11580 | NSP_30760 | NSP_11580 | Aspartate aminotransferase; Nsp30760; ORF_ID:nsp30760. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.821 |
NSP_30760 | NSP_38210 | NSP_30760 | NSP_38210 | Aspartate aminotransferase; Nsp30760; ORF_ID:nsp30760. | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.458 |
NSP_30760 | NSP_50740 | NSP_30760 | NSP_50740 | Aspartate aminotransferase; Nsp30760; ORF_ID:nsp30760. | 5,10-methylenetetrahydrofolate reductase; Nsp50740; ORF_ID:nsp50740; Belongs to the methylenetetrahydrofolate reductase family. | 0.516 |
NSP_33480 | NSP_11580 | NSP_33480 | NSP_11580 | N-succinyl-L,L-diaminopimelate aminotransferase alternative; Nsp33480; ORF_ID:nsp33480. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.821 |
NSP_33480 | NSP_38210 | NSP_33480 | NSP_38210 | N-succinyl-L,L-diaminopimelate aminotransferase alternative; Nsp33480; ORF_ID:nsp33480. | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.458 |
NSP_33480 | NSP_50740 | NSP_33480 | NSP_50740 | N-succinyl-L,L-diaminopimelate aminotransferase alternative; Nsp33480; ORF_ID:nsp33480. | 5,10-methylenetetrahydrofolate reductase; Nsp50740; ORF_ID:nsp50740; Belongs to the methylenetetrahydrofolate reductase family. | 0.516 |
NSP_38200 | NSP_38210 | NSP_38200 | NSP_38210 | Hypothetical protein; Nsp38200; ORF_ID:nsp38200. | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.773 |