Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (336 aa)    
Predicted Functional Partners:
NSP_31770
Uroporphyrinogen-III methyltransferase / Uroporphyrinogen-III synthase; Nsp31770; ORF_ID:nsp31770; Belongs to the precorrin methyltransferase family.
 0.999
NSP_35310
Porphobilinogen synthase; Nsp35310; ORF_ID:nsp35310; Belongs to the ALAD family.
 
 0.998
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.997
hemE
Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 0.997
NSP_24670
Uroporphyrinogen-III methyltransferase; Nsp24670; ORF_ID:nsp24670; Belongs to the precorrin methyltransferase family.
 
 0.993
hemL
Glutamate-1-semialdehyde aminotransferase; Nsp21010; ORF_ID:nsp21010.
  
 0.946
NSP_27020
Glutamate-1-semialdehyde aminotransferase; Nsp27020; ORF_ID:nsp27020; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.872
hemH
Ferrochelatase, protoheme ferro-lyase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.777
NSP_25820
Protoporphyrin IX Mg-chelatase subunit D; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
  
  
 0.744
pgl
6-phosphogluconolactonase, eukaryotic type; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
 
    
 0.722
Your Current Organism:
Nodularia spumigena
NCBI taxonomy Id: 313624
Other names: N. spumigena CCY9414, Nodularia spumigena CCY9414
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