STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NSP_493003-isopropylmalate dehydrogenase; Nsp49300; ORF_ID:nsp49300. (363 aa)    
Predicted Functional Partners:
NSP_49310
3-isopropylmalate dehydratase large subunit; Nsp49310; ORF_ID:nsp49310; Belongs to the aconitase/IPM isomerase family.
 0.999
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.996
NSP_42420
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.989
NSP_20200
Acetolactate synthase small subunit; Nsp20200; ORF_ID:nsp20200.
 
 0.947
ilvD
Dihydroxy-acid dehydratase; Nsp33730; ORF_ID:nsp33730; Belongs to the IlvD/Edd family.
 
  
 0.942
NSP_49390
2-isopropylmalate synthase; Nsp49390; ORF_ID:nsp49390; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 0.928
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.916
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 0.915
NSP_10510
Ferredoxin-dependent glutamate synthase; Nsp10510; ORF_ID:nsp10510.
 
 
 0.914
NSP_7960
Isocitrate dehydrogenase [NADP]; Nsp7960; ORF_ID:nsp7960.
 
0.909
Your Current Organism:
Nodularia spumigena
NCBI taxonomy Id: 313624
Other names: N. spumigena CCY9414, Nodularia spumigena CCY9414
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