EDM25167.1 protein (Lentisphaera araneosa) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

EDM25167.1

Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold. (296 aa)

Predicted Functional Partners:

EDM25168.1

0.950

EDM29517.1

0.795

EDM28872.1

0.785

EDM29515.1

0.785

EDM24668.1

0.785

EDM25166.1

0.773

aroB

0.768

EDM27347.1

0.767

EDM27303.1

0.685

EDM25169.1

0.675

Your Current Organism:

Lentisphaera araneosa

NCBI taxonomy Id: 313628
Other names: L. araneosa HTCC2155, Lentisphaera araneosa HTCC2155, Lentisphaera araneosa str. HTCC2155, Lentisphaera araneosa strain HTCC2155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDM24668.1	EDM25167.1	LNTAR_25587	LNTAR_24616	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	0.785
EDM24668.1	EDM25168.1	LNTAR_25587	LNTAR_24621	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	Hypothetical protein.	0.785
EDM24668.1	EDM27303.1	LNTAR_25587	LNTAR_21355	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	Putative large, multifunctional secreted protein; COG2133 Glucose/sorbosone dehydrogenases.	0.570
EDM24668.1	EDM27347.1	LNTAR_25587	LNTAR_21575	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	Transcriptional regulator, Crp/Fnr family protein; COG2133 Glucose/sorbosone dehydrogenases.	0.739
EDM24668.1	EDM28872.1	LNTAR_25587	LNTAR_13687	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	COG1524 Uncharacterized proteins of the AP superfamily.	0.778
EDM24668.1	EDM29517.1	LNTAR_25587	LNTAR_17243	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	Hypothetical protein; COG1082 Sugar phosphate isomerases/epimerases.	0.785
EDM24668.1	aroB	LNTAR_25587	LNTAR_17238	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	COG0337 3-dehydroquinate synthetase.	0.743
EDM25166.1	EDM25167.1	LNTAR_24611	LNTAR_24616	COG1934 Uncharacterized protein conserved in bacteria.	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	0.773
EDM25166.1	EDM25168.1	LNTAR_24611	LNTAR_24621	COG1934 Uncharacterized protein conserved in bacteria.	Hypothetical protein.	0.773
EDM25166.1	EDM25169.1	LNTAR_24611	LNTAR_24626	COG1934 Uncharacterized protein conserved in bacteria.	COG0165 Argininosuccinate lyase.	0.675
EDM25167.1	EDM24668.1	LNTAR_24616	LNTAR_25587	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	0.785
EDM25167.1	EDM25166.1	LNTAR_24616	LNTAR_24611	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	COG1934 Uncharacterized protein conserved in bacteria.	0.773
EDM25167.1	EDM25168.1	LNTAR_24616	LNTAR_24621	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	Hypothetical protein.	0.950
EDM25167.1	EDM25169.1	LNTAR_24616	LNTAR_24626	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	COG0165 Argininosuccinate lyase.	0.675
EDM25167.1	EDM27303.1	LNTAR_24616	LNTAR_21355	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	Putative large, multifunctional secreted protein; COG2133 Glucose/sorbosone dehydrogenases.	0.685
EDM25167.1	EDM27347.1	LNTAR_24616	LNTAR_21575	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	Transcriptional regulator, Crp/Fnr family protein; COG2133 Glucose/sorbosone dehydrogenases.	0.767
EDM25167.1	EDM28872.1	LNTAR_24616	LNTAR_13687	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	COG1524 Uncharacterized proteins of the AP superfamily.	0.785
EDM25167.1	EDM29515.1	LNTAR_24616	LNTAR_17233	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	Hypothetical protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases.	0.785
EDM25167.1	EDM29517.1	LNTAR_24616	LNTAR_17243	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	Hypothetical protein; COG1082 Sugar phosphate isomerases/epimerases.	0.795
EDM25167.1	aroB	LNTAR_24616	LNTAR_17238	Hydrolase, TatD family protein; COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold.	COG0337 3-dehydroquinate synthetase.	0.768

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Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.945

expected number of edges:

15

PPI enrichment p-value:

4.85e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

8 of 24

2.48

7.01

2.75e-15

GO:0019318

Hexose metabolic process

8 of 48

2.17

5.81

3.36e-14

GO:0006006

Glucose metabolic process

5 of 23

2.29

4.02

6.22e-09

GO:0006091

Generation of precursor metabolites and energy

9 of 162

1.7

3.73

1.20e-12

GO:0051156

Glucose 6-phosphate metabolic process

4 of 15

2.38

3.34

3.10e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 4

2.95

3.84

8.88e-08

GO:0008865

Fructokinase activity

3 of 7

2.58

2.27

6.25e-05

GO:0005536

Glucose binding

3 of 7

2.58

2.27

6.25e-05

GO:0004340

Glucokinase activity

3 of 7

2.58

2.27

6.25e-05

GO:0030246

Carbohydrate binding

4 of 63

1.76

1.77

0.00013

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

10 of 835

1.03

1.23

1.70e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9210

Glycolysis, and Pentose phosphate pathway

9 of 67

2.08

5.73

5.58e-15

CL:9224

Glycolytic process

5 of 14

2.51

4.37

3.02e-09

CL:9212

Glycolysis, and Pentose phosphate pathway

7 of 57

2.04

4.36

6.53e-11

CL:9241

Fructose-bisphosphate aldolase activity, and Triosephosphate isomerase

3 of 5

2.73

2.65

1.27e-05

CL:9331

Regulation of Glucokinase by Glucokinase Regulatory Protein, and Beta-mannosidase activity

2 of 5

2.55

1.27

0.0047

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

7 of 82

1.88

3.84

1.83e-10

map00030

Pentose phosphate pathway

5 of 31

2.16

3.69

1.65e-08

map00051

Fructose and mannose metabolism

5 of 54

1.92

3.08

8.67e-08

map00052

Galactose metabolism

5 of 61

1.87

2.94

1.29e-07

map00520

Amino sugar and nucleotide sugar metabolism

6 of 119

1.66

2.65

6.02e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-170822

Regulation of Glucokinase by Glucokinase Regulatory Protein

3 of 6

2.65

2.47

2.70e-05

MAP-70171

Glycolysis

4 of 27

2.12

2.45

1.21e-05

MAP-71387

Metabolism of carbohydrates

7 of 245

1.41

1.85

1.84e-06

MAP-70370

Galactose catabolism

2 of 7

2.41

1.19

0.0063

MAP-70326

Glucose metabolism

4 of 127

1.45

1.14

0.0021

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 15

2.48

4.42

2.16e-09

KW-0119

Carbohydrate metabolism

2 of 24

1.87

0.72

0.0430

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01116

Fructose-bisphosphate aldolase class-II

2 of 2

2.95

1.2

0.0068

PF03727

Hexokinase

2 of 6

2.48

0.98

0.0159

PF00349

Hexokinase

2 of 6

2.48

0.98

0.0159

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 2

2.95

0.95

0.0193

IPR022673

Hexokinase, C-terminal

2 of 6

2.48

0.74

0.0450

IPR022672

Hexokinase, N-terminal

2 of 6

2.48

0.74

0.0450

IPR001312

Hexokinase

2 of 6

2.48

0.74

0.0450

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