node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAQ80953.1 | EAQ82090.1 | DSM3645_20317 | DSM3645_00210 | Dihydroorotate dehydrogenase electron transfer subunit; COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases. | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | 0.471 |
EAQ80953.1 | ribBA | DSM3645_20317 | DSM3645_04380 | Dihydroorotate dehydrogenase electron transfer subunit; COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases. | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.764 |
EAQ82088.1 | EAQ82089.1 | DSM3645_00200 | DSM3645_00205 | Amine oxidase, flavin-containing; COG3380 Predicted NAD/FAD-dependent oxidoreductase. | Protein up-regulated by thyroid hormone-putative PQQ-dependent glucose dehydrogenase; COG2133 Glucose/sorbosone dehydrogenases. | 0.730 |
EAQ82088.1 | EAQ82090.1 | DSM3645_00200 | DSM3645_00210 | Amine oxidase, flavin-containing; COG3380 Predicted NAD/FAD-dependent oxidoreductase. | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | 0.482 |
EAQ82089.1 | EAQ82088.1 | DSM3645_00205 | DSM3645_00200 | Protein up-regulated by thyroid hormone-putative PQQ-dependent glucose dehydrogenase; COG2133 Glucose/sorbosone dehydrogenases. | Amine oxidase, flavin-containing; COG3380 Predicted NAD/FAD-dependent oxidoreductase. | 0.730 |
EAQ82089.1 | EAQ82090.1 | DSM3645_00205 | DSM3645_00210 | Protein up-regulated by thyroid hormone-putative PQQ-dependent glucose dehydrogenase; COG2133 Glucose/sorbosone dehydrogenases. | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | 0.532 |
EAQ82090.1 | EAQ80953.1 | DSM3645_00210 | DSM3645_20317 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | Dihydroorotate dehydrogenase electron transfer subunit; COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases. | 0.471 |
EAQ82090.1 | EAQ82088.1 | DSM3645_00210 | DSM3645_00200 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | Amine oxidase, flavin-containing; COG3380 Predicted NAD/FAD-dependent oxidoreductase. | 0.482 |
EAQ82090.1 | EAQ82089.1 | DSM3645_00210 | DSM3645_00205 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | Protein up-regulated by thyroid hormone-putative PQQ-dependent glucose dehydrogenase; COG2133 Glucose/sorbosone dehydrogenases. | 0.532 |
EAQ82090.1 | EAQ82091.1 | DSM3645_00210 | DSM3645_00215 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | Hypothetical protein; COG0384 Predicted epimerase, PhzC/PhzF homolog. | 0.525 |
EAQ82090.1 | EAQ82352.1 | DSM3645_00210 | DSM3645_01520 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | FolA, dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.752 |
EAQ82090.1 | gyrB | DSM3645_00210 | DSM3645_11911 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.784 |
EAQ82090.1 | pdxJ | DSM3645_00210 | DSM3645_27001 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | Pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.926 |
EAQ82090.1 | ribBA | DSM3645_00210 | DSM3645_04380 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.510 |
EAQ82090.1 | rsmA | DSM3645_00210 | DSM3645_23361 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.629 |
EAQ82090.1 | serC | DSM3645_00210 | DSM3645_20222 | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.774 |
EAQ82091.1 | EAQ82090.1 | DSM3645_00215 | DSM3645_00210 | Hypothetical protein; COG0384 Predicted epimerase, PhzC/PhzF homolog. | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | 0.525 |
EAQ82352.1 | EAQ82090.1 | DSM3645_01520 | DSM3645_00210 | FolA, dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | 0.752 |
gyrB | EAQ82090.1 | DSM3645_11911 | DSM3645_00210 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | 0.784 |
pdxJ | EAQ82090.1 | DSM3645_27001 | DSM3645_00210 | Pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. | 0.926 |