EAQ81002.1 protein (Blastopirellula marina) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

EAQ81002.1

Putative large multi-functional protein. (329 aa)

Predicted Functional Partners:

EAQ77927.1

0.953

EAQ78291.1

0.949

EAQ80282.1

0.767

EAQ77720.1

0.762

EAQ81175.1

0.758

EAQ77753.1

0.757

EAQ81050.1

0.745

EAQ77934.1

0.733

EAQ79100.1

0.731

EAQ78888.1

0.717

Your Current Organism:

Blastopirellula marina

NCBI taxonomy Id: 314230
Other names: B. marina DSM 3645, Blastopirellula marina DSM 3645, Blastopirellula marina str. DSM 3645, Blastopirellula marina strain DSM 3645

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAQ77720.1	EAQ77934.1	DSM3645_02096	DSM3645_27186	Hypothetical protein.	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	0.504
EAQ77720.1	EAQ78291.1	DSM3645_02096	DSM3645_18181	Hypothetical protein.	Putative large multi-functional protein; COG2133 Glucose/sorbosone dehydrogenases.	0.422
EAQ77720.1	EAQ79100.1	DSM3645_02096	DSM3645_14090	Hypothetical protein.	COG3828 Uncharacterized protein conserved in bacteria.	0.409
EAQ77720.1	EAQ81002.1	DSM3645_02096	DSM3645_20562	Hypothetical protein.	Putative large multi-functional protein.	0.762
EAQ77753.1	EAQ77934.1	DSM3645_25327	DSM3645_27186	Hypothetical protein.	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	0.556
EAQ77753.1	EAQ78888.1	DSM3645_25327	DSM3645_27448	Hypothetical protein.	Hypothetical protein.	0.927
EAQ77753.1	EAQ79100.1	DSM3645_25327	DSM3645_14090	Hypothetical protein.	COG3828 Uncharacterized protein conserved in bacteria.	0.927
EAQ77753.1	EAQ80282.1	DSM3645_25327	DSM3645_19838	Hypothetical protein.	Hypothetical protein.	0.771
EAQ77753.1	EAQ81002.1	DSM3645_25327	DSM3645_20562	Hypothetical protein.	Putative large multi-functional protein.	0.757
EAQ77927.1	EAQ80282.1	DSM3645_27151	DSM3645_19838	Probable large, multifunctional secreted protein; COG2133 Glucose/sorbosone dehydrogenases.	Hypothetical protein.	0.590
EAQ77927.1	EAQ81002.1	DSM3645_27151	DSM3645_20562	Probable large, multifunctional secreted protein; COG2133 Glucose/sorbosone dehydrogenases.	Putative large multi-functional protein.	0.953
EAQ77934.1	EAQ77720.1	DSM3645_27186	DSM3645_02096	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	Hypothetical protein.	0.504
EAQ77934.1	EAQ77753.1	DSM3645_27186	DSM3645_25327	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	Hypothetical protein.	0.556
EAQ77934.1	EAQ78888.1	DSM3645_27186	DSM3645_27448	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	Hypothetical protein.	0.464
EAQ77934.1	EAQ80282.1	DSM3645_27186	DSM3645_19838	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	Hypothetical protein.	0.461
EAQ77934.1	EAQ81002.1	DSM3645_27186	DSM3645_20562	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	Putative large multi-functional protein.	0.733
EAQ77934.1	EAQ81050.1	DSM3645_27186	DSM3645_20802	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	Hypothetical protein.	0.414
EAQ77934.1	EAQ81175.1	DSM3645_27186	DSM3645_21427	Hypothetical protein; COG3622 Hydroxypyruvate isomerase.	Probable secreted glycosyl hydrolase.	0.465
EAQ78291.1	EAQ77720.1	DSM3645_18181	DSM3645_02096	Putative large multi-functional protein; COG2133 Glucose/sorbosone dehydrogenases.	Hypothetical protein.	0.422
EAQ78291.1	EAQ80282.1	DSM3645_18181	DSM3645_19838	Putative large multi-functional protein; COG2133 Glucose/sorbosone dehydrogenases.	Hypothetical protein.	0.634

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.868

expected number of edges:

12

PPI enrichment p-value:

0.0469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009089

Lysine biosynthetic process via diaminopimelate

6 of 16

1.93

3.16

5.50e-08

GO:0043648

Dicarboxylic acid metabolic process

7 of 32

1.69

2.75

4.50e-08

GO:0019877

Diaminopimelate biosynthetic process

4 of 10

1.95

2.31

1.35e-05

GO:0043650

Dicarboxylic acid biosynthetic process

5 of 21

1.73

2.28

3.57e-06

GO:0008652

Cellular amino acid biosynthetic process

8 of 91

1.3

1.79

1.28e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030170

Pyridoxal phosphate binding

4 of 21

1.63

1.3

0.0015

GO:0008483

Transaminase activity

3 of 15

1.65

1.03

0.0074

GO:0003824

Catalytic activity

11 of 1196

0.31

0.25

0.0340

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 923

0.39

0.27

0.0415

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1636

Lysine biosynthesis, and Threonine biosynthetic process

8 of 13

2.14

5.31

5.32e-13

CL:1638

Diaminopimelate biosynthesis

5 of 5

2.35

3.96

1.19e-08

CL:1596

Cysteine and methionine metabolism, and Lysine biosynthesis

9 of 38

1.73

3.79

2.13e-12

CL:1416

Biosynthesis of amino acids, and Oxidoreductase activity

10 of 128

1.24

1.91

3.07e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00300

Lysine biosynthesis

10 of 31

1.86

5.03

5.66e-16

map01230

Biosynthesis of amino acids

11 of 121

1.31

2.32

3.58e-13

map00261

Monobactam biosynthesis

3 of 5

2.13

2.04

9.96e-05

map01110

Biosynthesis of secondary metabolites

11 of 306

0.91

1.06

4.70e-09

map01120

Microbial metabolism in diverse environments

6 of 179

0.88

0.73

0.00099

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0457

Lysine biosynthesis

7 of 7

2.35

5.6

1.78e-12

KW-0220

Diaminopimelate biosynthesis

5 of 5

2.35

3.94

1.34e-08

KW-0032

Aminotransferase

3 of 14

1.68

1.28

0.0019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01041

DegT/DnrJ/EryC1/StrS aminotransferase family

3 of 4

2.23

1.62

0.00083

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004838

Aminotransferases, class-I, pyridoxal-phosphate-binding site

3 of 4

2.23

1.39

0.0024

IPR004839

Aminotransferase, class I/classII

3 of 9

1.87

1.09

0.0075

IPR015424

Pyridoxal phosphate-dependent transferase

3 of 21

1.51

0.66

0.0446

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

3 of 21

1.51

0.66

0.0446

IPR015421

Pyridoxal phosphate-dependent transferase, major domain

3 of 21

1.51

0.66

0.0446

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