| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ05637.1 | EAQ07119.1 | SKA53_01084 | SKA53_01946 | Haloacid dehalogenase, type II; COG1011 Predicted hydrolase (HAD superfamily). | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.878 |
| EAQ05637.1 | ribB | SKA53_01084 | SKA53_01971 | Haloacid dehalogenase, type II; COG1011 Predicted hydrolase (HAD superfamily). | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.412 |
| EAQ05837.1 | EAQ07119.1 | SKA53_07022 | SKA53_01946 | Pyrimidine 5'-nucleotidase; COG1011 Predicted hydrolase (HAD superfamily). | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.878 |
| EAQ05837.1 | ribB | SKA53_07022 | SKA53_01971 | Pyrimidine 5'-nucleotidase; COG1011 Predicted hydrolase (HAD superfamily). | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.412 |
| EAQ06682.1 | EAQ07119.1 | SKA53_14081 | SKA53_01946 | HAD-superfamily hydrolase, subfamily IA, variant 1 family protein; COG1011 Predicted hydrolase (HAD superfamily). | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.878 |
| EAQ06682.1 | EAQ07123.1 | SKA53_14081 | SKA53_01966 | HAD-superfamily hydrolase, subfamily IA, variant 1 family protein; COG1011 Predicted hydrolase (HAD superfamily). | COG0307 Riboflavin synthase alpha chain. | 0.444 |
| EAQ06682.1 | ribB | SKA53_14081 | SKA53_01971 | HAD-superfamily hydrolase, subfamily IA, variant 1 family protein; COG1011 Predicted hydrolase (HAD superfamily). | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.412 |
| EAQ06682.1 | ribH | SKA53_14081 | SKA53_01976 | HAD-superfamily hydrolase, subfamily IA, variant 1 family protein; COG1011 Predicted hydrolase (HAD superfamily). | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.451 |
| EAQ06805.1 | EAQ07119.1 | SKA53_14696 | SKA53_01946 | Protease, putative; COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.858 |
| EAQ07119.1 | EAQ05637.1 | SKA53_01946 | SKA53_01084 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Haloacid dehalogenase, type II; COG1011 Predicted hydrolase (HAD superfamily). | 0.878 |
| EAQ07119.1 | EAQ05837.1 | SKA53_01946 | SKA53_07022 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Pyrimidine 5'-nucleotidase; COG1011 Predicted hydrolase (HAD superfamily). | 0.878 |
| EAQ07119.1 | EAQ06682.1 | SKA53_01946 | SKA53_14081 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | HAD-superfamily hydrolase, subfamily IA, variant 1 family protein; COG1011 Predicted hydrolase (HAD superfamily). | 0.878 |
| EAQ07119.1 | EAQ06805.1 | SKA53_01946 | SKA53_14696 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Protease, putative; COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone. | 0.858 |
| EAQ07119.1 | EAQ07123.1 | SKA53_01946 | SKA53_01966 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COG0307 Riboflavin synthase alpha chain. | 0.999 |
| EAQ07119.1 | EAQ07160.1 | SKA53_01946 | SKA53_02151 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Biotin carboxyl carrier protein, AccB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.815 |
| EAQ07119.1 | nrdR | SKA53_01946 | SKA53_01941 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.943 |
| EAQ07119.1 | ribA | SKA53_01946 | SKA53_10264 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.998 |
| EAQ07119.1 | ribB | SKA53_01946 | SKA53_01971 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
| EAQ07119.1 | ribH | SKA53_01946 | SKA53_01976 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.998 |
| EAQ07123.1 | EAQ06682.1 | SKA53_01966 | SKA53_14081 | COG0307 Riboflavin synthase alpha chain. | HAD-superfamily hydrolase, subfamily IA, variant 1 family protein; COG1011 Predicted hydrolase (HAD superfamily). | 0.444 |