| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06714.1 | EAQ07217.1 | SKA53_14241 | SKA53_02436 | COG2249 putative NADPH-quinone reductase (modulator of drug activity B). | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | 0.787 |
| EAQ07119.1 | EAQ07216.1 | SKA53_01946 | SKA53_02431 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COG1748 Saccharopine dehydrogenase and related proteins. | 0.435 |
| EAQ07119.1 | EAQ07217.1 | SKA53_01946 | SKA53_02436 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | 0.537 |
| EAQ07119.1 | dapF | SKA53_01946 | SKA53_12208 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.629 |
| EAQ07119.1 | guaA | SKA53_01946 | SKA53_04933 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.667 |
| EAQ07119.1 | guaB | SKA53_01946 | SKA53_03244 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.665 |
| EAQ07119.1 | murE | SKA53_01946 | SKA53_07286 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.458 |
| EAQ07119.1 | ribB | SKA53_01946 | SKA53_01971 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
| EAQ07216.1 | EAQ07119.1 | SKA53_02431 | SKA53_01946 | COG1748 Saccharopine dehydrogenase and related proteins. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.435 |
| EAQ07216.1 | EAQ07217.1 | SKA53_02431 | SKA53_02436 | COG1748 Saccharopine dehydrogenase and related proteins. | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | 0.985 |
| EAQ07216.1 | dapF | SKA53_02431 | SKA53_12208 | COG1748 Saccharopine dehydrogenase and related proteins. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.467 |
| EAQ07216.1 | murE | SKA53_02431 | SKA53_07286 | COG1748 Saccharopine dehydrogenase and related proteins. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.535 |
| EAQ07217.1 | EAQ06714.1 | SKA53_02436 | SKA53_14241 | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | COG2249 putative NADPH-quinone reductase (modulator of drug activity B). | 0.787 |
| EAQ07217.1 | EAQ07119.1 | SKA53_02436 | SKA53_01946 | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.537 |
| EAQ07217.1 | EAQ07216.1 | SKA53_02436 | SKA53_02431 | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | COG1748 Saccharopine dehydrogenase and related proteins. | 0.985 |
| EAQ07217.1 | asd | SKA53_02436 | SKA53_10149 | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.528 |
| EAQ07217.1 | dapF | SKA53_02436 | SKA53_12208 | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.543 |
| EAQ07217.1 | glpK | SKA53_02436 | SKA53_08181 | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.763 |
| EAQ07217.1 | guaA | SKA53_02436 | SKA53_04933 | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.577 |
| EAQ07217.1 | guaB | SKA53_02436 | SKA53_03244 | NspC, carboxynorspermidine decarboxylase; COG0019 Diaminopimelate decarboxylase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.593 |