| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06347.1 | EAQ07266.1 | SKA53_04648 | SKA53_02681 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.978 |
| EAQ06347.1 | EAQ07361.1 | SKA53_04648 | SKA53_03156 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | CobA, uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.903 |
| EAQ06347.1 | EAQ08049.1 | SKA53_04648 | SKA53_10004 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Precorrin-3B C17-methyltransferase region; COG2073 Cobalamin biosynthesis protein CbiG. | 0.661 |
| EAQ06347.1 | EAQ08051.1 | SKA53_04648 | SKA53_10014 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | CobL, precorrin-6Y C5,15-methyltransferase; COG2241 Precorrin-6B methylase 1. | 0.658 |
| EAQ06347.1 | hemC | SKA53_04648 | SKA53_08216 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
| EAQ07263.1 | EAQ07264.1 | SKA53_02666 | SKA53_02671 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.999 |
| EAQ07263.1 | EAQ07266.1 | SKA53_02666 | SKA53_02681 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.998 |
| EAQ07263.1 | EAQ07361.1 | SKA53_02666 | SKA53_03156 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | CobA, uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.900 |
| EAQ07263.1 | EAQ08053.1 | SKA53_02666 | SKA53_10024 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | Hypothetical protein. | 0.604 |
| EAQ07263.1 | cysC | SKA53_02666 | SKA53_08711 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | Binfunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. | 0.999 |
| EAQ07264.1 | EAQ07263.1 | SKA53_02671 | SKA53_02666 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.999 |
| EAQ07264.1 | EAQ07266.1 | SKA53_02671 | SKA53_02681 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.997 |
| EAQ07264.1 | EAQ07361.1 | SKA53_02671 | SKA53_03156 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | CobA, uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.909 |
| EAQ07264.1 | EAQ08049.1 | SKA53_02671 | SKA53_10004 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Precorrin-3B C17-methyltransferase region; COG2073 Cobalamin biosynthesis protein CbiG. | 0.938 |
| EAQ07264.1 | EAQ08050.1 | SKA53_02671 | SKA53_10009 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Cobalamin biosynthesis precorrin-2 methyltransferase; COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.611 |
| EAQ07264.1 | EAQ08051.1 | SKA53_02671 | SKA53_10014 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | CobL, precorrin-6Y C5,15-methyltransferase; COG2241 Precorrin-6B methylase 1. | 0.942 |
| EAQ07264.1 | EAQ08053.1 | SKA53_02671 | SKA53_10024 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Hypothetical protein. | 0.486 |
| EAQ07264.1 | cysC | SKA53_02671 | SKA53_08711 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Binfunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. | 0.992 |
| EAQ07266.1 | EAQ06347.1 | SKA53_02681 | SKA53_04648 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.978 |
| EAQ07266.1 | EAQ07263.1 | SKA53_02681 | SKA53_02666 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.998 |