| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06657.1 | murD | SKA53_13956 | SKA53_07271 | Hypothetical protein. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.815 |
| EAQ06657.1 | murI | SKA53_13956 | SKA53_02936 | Hypothetical protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.815 |
| EAQ06657.1 | purQ | SKA53_13956 | SKA53_03444 | Hypothetical protein. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.815 |
| EAQ06935.1 | EAQ07111.1 | SKA53_15346 | SKA53_01906 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.923 |
| EAQ06935.1 | EAQ08075.1 | SKA53_15346 | SKA53_10134 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | 0.529 |
| EAQ06935.1 | EAQ08212.1 | SKA53_15346 | SKA53_10819 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.902 |
| EAQ06935.1 | murI | SKA53_15346 | SKA53_02936 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.889 |
| EAQ06935.1 | purQ | SKA53_15346 | SKA53_03444 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.820 |
| EAQ07111.1 | EAQ06935.1 | SKA53_01906 | SKA53_15346 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.923 |
| EAQ07111.1 | EAQ08212.1 | SKA53_01906 | SKA53_10819 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.988 |
| EAQ07111.1 | murI | SKA53_01906 | SKA53_02936 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.865 |
| EAQ07111.1 | purQ | SKA53_01906 | SKA53_03444 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.831 |
| EAQ07525.1 | EAQ08212.1 | SKA53_11848 | SKA53_10819 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.564 |
| EAQ07525.1 | murD | SKA53_11848 | SKA53_07271 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.457 |
| EAQ07525.1 | murI | SKA53_11848 | SKA53_02936 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.904 |
| EAQ08075.1 | EAQ06935.1 | SKA53_10134 | SKA53_15346 | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.529 |
| EAQ08075.1 | EAQ08212.1 | SKA53_10134 | SKA53_10819 | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.414 |
| EAQ08075.1 | murI | SKA53_10134 | SKA53_02936 | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.815 |
| EAQ08212.1 | EAQ06935.1 | SKA53_10819 | SKA53_15346 | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.902 |
| EAQ08212.1 | EAQ07111.1 | SKA53_10819 | SKA53_01906 | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.988 |