| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ05267.1 | EAQ06519.1 | SKA53_05810 | SKA53_05508 | COG0174 Glutamine synthetase. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.475 |
| EAQ05267.1 | EAQ08212.1 | SKA53_05810 | SKA53_10819 | COG0174 Glutamine synthetase. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.935 |
| EAQ05267.1 | nadE | SKA53_05810 | SKA53_08994 | COG0174 Glutamine synthetase. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.605 |
| EAQ06061.1 | EAQ06392.1 | SKA53_08146 | SKA53_04873 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.917 |
| EAQ06061.1 | EAQ06519.1 | SKA53_08146 | SKA53_05508 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.464 |
| EAQ06061.1 | EAQ08212.1 | SKA53_08146 | SKA53_10819 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.453 |
| EAQ06061.1 | nadE | SKA53_08146 | SKA53_08994 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.612 |
| EAQ06392.1 | EAQ06061.1 | SKA53_04873 | SKA53_08146 | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.917 |
| EAQ06392.1 | EAQ06519.1 | SKA53_04873 | SKA53_05508 | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.519 |
| EAQ06392.1 | EAQ08212.1 | SKA53_04873 | SKA53_10819 | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.420 |
| EAQ06392.1 | glnD | SKA53_04873 | SKA53_14731 | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.603 |
| EAQ06518.1 | EAQ06519.1 | SKA53_05503 | SKA53_05508 | Hypothetical protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.857 |
| EAQ06518.1 | EAQ06520.1 | SKA53_05503 | SKA53_05513 | Hypothetical protein. | Hypothetical protein. | 0.710 |
| EAQ06518.1 | EAQ06521.1 | SKA53_05503 | SKA53_05518 | Hypothetical protein. | Hypothetical protein. | 0.566 |
| EAQ06519.1 | EAQ05267.1 | SKA53_05508 | SKA53_05810 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | COG0174 Glutamine synthetase. | 0.475 |
| EAQ06519.1 | EAQ06061.1 | SKA53_05508 | SKA53_08146 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.464 |
| EAQ06519.1 | EAQ06392.1 | SKA53_05508 | SKA53_04873 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.519 |
| EAQ06519.1 | EAQ06518.1 | SKA53_05508 | SKA53_05503 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Hypothetical protein. | 0.857 |
| EAQ06519.1 | EAQ06520.1 | SKA53_05508 | SKA53_05513 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Hypothetical protein. | 0.710 |
| EAQ06519.1 | EAQ06521.1 | SKA53_05508 | SKA53_05518 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Hypothetical protein. | 0.632 |
