| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ05839.1 | EAQ05840.1 | SKA53_07032 | SKA53_07037 | Aminotransferase family protein; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | 0.670 |
| EAQ05839.1 | EAQ05841.1 | SKA53_07032 | SKA53_07042 | Aminotransferase family protein; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | 0.669 |
| EAQ05839.1 | EAQ08212.1 | SKA53_07032 | SKA53_10819 | Aminotransferase family protein; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.556 |
| EAQ05839.1 | ilvC | SKA53_07032 | SKA53_07047 | Aminotransferase family protein; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.543 |
| EAQ05840.1 | EAQ05839.1 | SKA53_07037 | SKA53_07032 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Aminotransferase family protein; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.670 |
| EAQ05840.1 | EAQ05841.1 | SKA53_07037 | SKA53_07042 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | 0.880 |
| EAQ05840.1 | EAQ05843.1 | SKA53_07037 | SKA53_07052 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | 0.423 |
| EAQ05840.1 | EAQ07266.1 | SKA53_07037 | SKA53_02681 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.658 |
| EAQ05840.1 | EAQ08212.1 | SKA53_07037 | SKA53_10819 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.519 |
| EAQ05840.1 | ilvC | SKA53_07037 | SKA53_07047 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.704 |
| EAQ05841.1 | EAQ05839.1 | SKA53_07042 | SKA53_07032 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Aminotransferase family protein; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.669 |
| EAQ05841.1 | EAQ05840.1 | SKA53_07042 | SKA53_07037 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | 0.880 |
| EAQ05841.1 | EAQ05843.1 | SKA53_07042 | SKA53_07052 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | 0.424 |
| EAQ05841.1 | EAQ07266.1 | SKA53_07042 | SKA53_02681 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.658 |
| EAQ05841.1 | EAQ08212.1 | SKA53_07042 | SKA53_10819 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Glutamine-pyruvate aminotransferase; COG0067 Glutamate synthase domain 1. | 0.519 |
| EAQ05841.1 | ilvC | SKA53_07042 | SKA53_07047 | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.704 |
| EAQ05843.1 | EAQ05840.1 | SKA53_07052 | SKA53_07037 | Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | 0.423 |
| EAQ05843.1 | EAQ05841.1 | SKA53_07052 | SKA53_07042 | Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | 0.424 |
| EAQ05843.1 | ilvC | SKA53_07052 | SKA53_07047 | Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.632 |
| EAQ07266.1 | EAQ05840.1 | SKA53_02681 | SKA53_07037 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Transcriptional regulator, AsnC family; COG1522 Transcriptional regulators. | 0.658 |