| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ05845.1 | EAQ05846.1 | SKA53_07062 | SKA53_07067 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | 0.999 |
| EAQ05845.1 | EAQ05847.1 | SKA53_07062 | SKA53_07072 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Hypothetical protein; COG3773 Cell wall hydrolyses involved in spore germination. | 0.621 |
| EAQ05845.1 | EAQ06639.1 | SKA53_07062 | SKA53_13866 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.998 |
| EAQ05845.1 | EAQ07119.1 | SKA53_07062 | SKA53_01946 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.689 |
| EAQ05845.1 | EAQ07769.1 | SKA53_07062 | SKA53_13068 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.998 |
| EAQ05845.1 | folE2 | SKA53_07062 | SKA53_02116 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.575 |
| EAQ05845.1 | ftsH | SKA53_07062 | SKA53_08551 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.476 |
| EAQ05845.1 | glmM | SKA53_07062 | SKA53_07057 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.901 |
| EAQ05846.1 | EAQ05845.1 | SKA53_07067 | SKA53_07062 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| EAQ05846.1 | EAQ05847.1 | SKA53_07067 | SKA53_07072 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Hypothetical protein; COG3773 Cell wall hydrolyses involved in spore germination. | 0.621 |
| EAQ05846.1 | EAQ06173.1 | SKA53_07067 | SKA53_08706 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Hypothetical protein. | 0.564 |
| EAQ05846.1 | EAQ06639.1 | SKA53_07067 | SKA53_13866 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.818 |
| EAQ05846.1 | EAQ07119.1 | SKA53_07067 | SKA53_01946 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.684 |
| EAQ05846.1 | EAQ07769.1 | SKA53_07067 | SKA53_13068 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.994 |
| EAQ05846.1 | folE2 | SKA53_07067 | SKA53_02116 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.823 |
| EAQ05846.1 | ftsH | SKA53_07067 | SKA53_08551 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.573 |
| EAQ05846.1 | glmM | SKA53_07067 | SKA53_07057 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.817 |
| EAQ05846.1 | ispDF | SKA53_07067 | SKA53_04883 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). | 0.684 |
| EAQ05847.1 | EAQ05845.1 | SKA53_07072 | SKA53_07062 | Hypothetical protein; COG3773 Cell wall hydrolyses involved in spore germination. | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.621 |
| EAQ05847.1 | EAQ05846.1 | SKA53_07072 | SKA53_07067 | Hypothetical protein; COG3773 Cell wall hydrolyses involved in spore germination. | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | 0.621 |