| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ05903.1 | EAQ05906.1 | SKA53_07356 | SKA53_07371 | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Transglycosylase SLT domain protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). | 0.458 |
| EAQ05903.1 | EAQ06926.1 | SKA53_07356 | SKA53_15301 | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.499 |
| EAQ05903.1 | hisB | SKA53_07356 | SKA53_07361 | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.524 |
| EAQ05903.1 | hisC | SKA53_07356 | SKA53_09649 | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.499 |
| EAQ05903.1 | hisF | SKA53_07356 | SKA53_07386 | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.499 |
| EAQ05903.1 | hisH | SKA53_07356 | SKA53_07366 | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.752 |
| EAQ05906.1 | EAQ05903.1 | SKA53_07371 | SKA53_07356 | Transglycosylase SLT domain protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.458 |
| EAQ05906.1 | hisB | SKA53_07371 | SKA53_07361 | Transglycosylase SLT domain protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.681 |
| EAQ05906.1 | hisH | SKA53_07371 | SKA53_07366 | Transglycosylase SLT domain protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.707 |
| EAQ06926.1 | EAQ05903.1 | SKA53_15301 | SKA53_07356 | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.499 |
| EAQ06926.1 | hisB | SKA53_15301 | SKA53_07361 | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.996 |
| EAQ06926.1 | hisF | SKA53_15301 | SKA53_07386 | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.952 |
| EAQ06926.1 | hisH | SKA53_15301 | SKA53_07366 | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.967 |
| hisB | EAQ05903.1 | SKA53_07361 | SKA53_07356 | COG0131 Imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.524 |
| hisB | EAQ05906.1 | SKA53_07361 | SKA53_07371 | COG0131 Imidazoleglycerol-phosphate dehydratase. | Transglycosylase SLT domain protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). | 0.681 |
| hisB | EAQ06926.1 | SKA53_07361 | SKA53_15301 | COG0131 Imidazoleglycerol-phosphate dehydratase. | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.996 |
| hisB | hisC | SKA53_07361 | SKA53_09649 | COG0131 Imidazoleglycerol-phosphate dehydratase. | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.997 |
| hisB | hisF | SKA53_07361 | SKA53_07386 | COG0131 Imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisB | hisH | SKA53_07361 | SKA53_07366 | COG0131 Imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisC | EAQ05903.1 | SKA53_09649 | SKA53_07356 | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazoleglycerol-phosphate dehydratase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.499 |