| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ05447.1 | EAQ06077.1 | SKA53_03524 | SKA53_08226 | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COG0408 Coproporphyrinogen III oxidase. | 0.925 |
| EAQ05447.1 | EAQ06347.1 | SKA53_03524 | SKA53_04648 | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.426 |
| EAQ05447.1 | EAQ07526.1 | SKA53_03524 | SKA53_11853 | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.553 |
| EAQ05447.1 | EAQ07533.1 | SKA53_03524 | SKA53_11888 | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Membrane protein, putative; COG1981 Predicted membrane protein. | 0.899 |
| EAQ05447.1 | hemC | SKA53_03524 | SKA53_08216 | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.489 |
| EAQ05447.1 | hemE | SKA53_03524 | SKA53_08221 | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.970 |
| EAQ05447.1 | hemH | SKA53_03524 | SKA53_11743 | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.505 |
| EAQ06077.1 | EAQ05447.1 | SKA53_08226 | SKA53_03524 | COG0408 Coproporphyrinogen III oxidase. | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.925 |
| EAQ06077.1 | EAQ06078.1 | SKA53_08226 | SKA53_08231 | COG0408 Coproporphyrinogen III oxidase. | Hypothetical protein. | 0.640 |
| EAQ06077.1 | EAQ06347.1 | SKA53_08226 | SKA53_04648 | COG0408 Coproporphyrinogen III oxidase. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.576 |
| EAQ06077.1 | EAQ07526.1 | SKA53_08226 | SKA53_11853 | COG0408 Coproporphyrinogen III oxidase. | Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.687 |
| EAQ06077.1 | EAQ07533.1 | SKA53_08226 | SKA53_11888 | COG0408 Coproporphyrinogen III oxidase. | Membrane protein, putative; COG1981 Predicted membrane protein. | 0.931 |
| EAQ06077.1 | ctaB | SKA53_08226 | SKA53_08416 | COG0408 Coproporphyrinogen III oxidase. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.547 |
| EAQ06077.1 | hemC | SKA53_08226 | SKA53_08216 | COG0408 Coproporphyrinogen III oxidase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.580 |
| EAQ06077.1 | hemE | SKA53_08226 | SKA53_08221 | COG0408 Coproporphyrinogen III oxidase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.979 |
| EAQ06077.1 | hemH | SKA53_08226 | SKA53_11743 | COG0408 Coproporphyrinogen III oxidase. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.745 |
| EAQ06077.1 | nadD | SKA53_08226 | SKA53_14836 | COG0408 Coproporphyrinogen III oxidase. | Nicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.568 |
| EAQ06078.1 | EAQ06077.1 | SKA53_08231 | SKA53_08226 | Hypothetical protein. | COG0408 Coproporphyrinogen III oxidase. | 0.640 |
| EAQ06347.1 | EAQ05447.1 | SKA53_04648 | SKA53_03524 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Coproporphyrinogen III oxidase, oxygen-independent (HemN); COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.426 |
| EAQ06347.1 | EAQ06077.1 | SKA53_04648 | SKA53_08226 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | COG0408 Coproporphyrinogen III oxidase. | 0.576 |