| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06090.1 | EAQ07905.1 | SKA53_08291 | SKA53_09284 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.857 |
| EAQ06090.1 | cpdB | SKA53_08291 | SKA53_08296 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.779 |
| EAQ06090.1 | surE | SKA53_08291 | SKA53_02561 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.864 |
| EAQ06533.1 | EAQ07905.1 | SKA53_05578 | SKA53_09284 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.857 |
| EAQ06533.1 | EAQ07921.1 | SKA53_05578 | SKA53_09364 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | COG1816 Adenosine deaminase. | 0.889 |
| EAQ06533.1 | EAQ07924.1 | SKA53_05578 | SKA53_09379 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.687 |
| EAQ06533.1 | cpdB | SKA53_05578 | SKA53_08296 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.866 |
| EAQ06533.1 | guaA | SKA53_05578 | SKA53_04933 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.408 |
| EAQ06533.1 | mtnP | SKA53_05578 | SKA53_08366 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.810 |
| EAQ06533.1 | surE | SKA53_05578 | SKA53_02561 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.856 |
| EAQ07905.1 | EAQ06090.1 | SKA53_09284 | SKA53_08291 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | 0.857 |
| EAQ07905.1 | EAQ06533.1 | SKA53_09284 | SKA53_05578 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | 0.857 |
| EAQ07905.1 | EAQ07921.1 | SKA53_09284 | SKA53_09364 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | COG1816 Adenosine deaminase. | 0.940 |
| EAQ07905.1 | EAQ07924.1 | SKA53_09284 | SKA53_09379 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.889 |
| EAQ07905.1 | cpdB | SKA53_09284 | SKA53_08296 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.891 |
| EAQ07905.1 | cysC | SKA53_09284 | SKA53_08711 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Binfunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. | 0.859 |
| EAQ07905.1 | deoD | SKA53_09284 | SKA53_14611 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | COG0813 Purine-nucleoside phosphorylase. | 0.922 |
| EAQ07905.1 | guaA | SKA53_09284 | SKA53_04933 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.867 |
| EAQ07905.1 | mtnP | SKA53_09284 | SKA53_08366 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.763 |
| EAQ07905.1 | surE | SKA53_09284 | SKA53_02561 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.866 |