| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06579.1 | EAQ06925.1 | SKA53_13566 | SKA53_15296 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.505 |
| EAQ06579.1 | EAQ08025.1 | SKA53_13566 | SKA53_09884 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.774 |
| EAQ06579.1 | EAQ08027.1 | SKA53_13566 | SKA53_09894 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Threonine aldolase, low-specificity; COG3616 Predicted amino acid aldolase or racemase. | 0.699 |
| EAQ06579.1 | fumC | SKA53_13566 | SKA53_03499 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.430 |
| EAQ06579.1 | mdh | SKA53_13566 | SKA53_14541 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.514 |
| EAQ06925.1 | EAQ06579.1 | SKA53_15296 | SKA53_13566 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.505 |
| EAQ06925.1 | EAQ07731.1 | SKA53_15296 | SKA53_12878 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | L-threonine aldolase, low-specificity, putative; COG2008 Threonine aldolase. | 0.737 |
| EAQ06925.1 | EAQ08025.1 | SKA53_15296 | SKA53_09884 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.772 |
| EAQ06925.1 | EAQ08026.1 | SKA53_15296 | SKA53_09889 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | COG1171 Threonine dehydratase. | 0.409 |
| EAQ06925.1 | EAQ08027.1 | SKA53_15296 | SKA53_09894 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Threonine aldolase, low-specificity; COG3616 Predicted amino acid aldolase or racemase. | 0.748 |
| EAQ06925.1 | EAQ08028.1 | SKA53_15296 | SKA53_09899 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog. | 0.618 |
| EAQ06925.1 | fumC | SKA53_15296 | SKA53_03499 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.784 |
| EAQ06925.1 | glyA | SKA53_15296 | SKA53_09419 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.598 |
| EAQ06925.1 | glyA-2 | SKA53_15296 | SKA53_10924 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.598 |
| EAQ06925.1 | mdh | SKA53_15296 | SKA53_14541 | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.774 |
| EAQ07731.1 | EAQ06925.1 | SKA53_12878 | SKA53_15296 | L-threonine aldolase, low-specificity, putative; COG2008 Threonine aldolase. | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.737 |
| EAQ07731.1 | EAQ08025.1 | SKA53_12878 | SKA53_09884 | L-threonine aldolase, low-specificity, putative; COG2008 Threonine aldolase. | Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.862 |
| EAQ07731.1 | EAQ08026.1 | SKA53_12878 | SKA53_09889 | L-threonine aldolase, low-specificity, putative; COG2008 Threonine aldolase. | COG1171 Threonine dehydratase. | 0.578 |
| EAQ07731.1 | glyA | SKA53_12878 | SKA53_09419 | L-threonine aldolase, low-specificity, putative; COG2008 Threonine aldolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.818 |
| EAQ07731.1 | glyA-2 | SKA53_12878 | SKA53_10924 | L-threonine aldolase, low-specificity, putative; COG2008 Threonine aldolase. | Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.818 |