| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ07264.1 | EAQ07266.1 | SKA53_02671 | SKA53_02681 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.997 |
| EAQ07264.1 | EAQ08048.1 | SKA53_02671 | SKA53_09999 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | COG2875 Precorrin-4 methylase. | 0.660 |
| EAQ07264.1 | EAQ08049.1 | SKA53_02671 | SKA53_10004 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Precorrin-3B C17-methyltransferase region; COG2073 Cobalamin biosynthesis protein CbiG. | 0.938 |
| EAQ07264.1 | EAQ08050.1 | SKA53_02671 | SKA53_10009 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Cobalamin biosynthesis precorrin-2 methyltransferase; COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.611 |
| EAQ07264.1 | EAQ08051.1 | SKA53_02671 | SKA53_10014 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | CobL, precorrin-6Y C5,15-methyltransferase; COG2241 Precorrin-6B methylase 1. | 0.942 |
| EAQ07264.1 | EAQ08052.1 | SKA53_02671 | SKA53_10019 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | precorrin-8X methylmutase; COG2082 Precorrin isomerase. | 0.589 |
| EAQ07264.1 | EAQ08053.1 | SKA53_02671 | SKA53_10024 | COG0155 Sulfite reductase, beta subunit (hemoprotein). | Hypothetical protein. | 0.486 |
| EAQ07266.1 | EAQ07264.1 | SKA53_02681 | SKA53_02671 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.997 |
| EAQ07266.1 | EAQ07363.1 | SKA53_02681 | SKA53_03166 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | COG2099 Precorrin-6x reductase. | 0.919 |
| EAQ07266.1 | EAQ08048.1 | SKA53_02681 | SKA53_09999 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | COG2875 Precorrin-4 methylase. | 0.917 |
| EAQ07266.1 | EAQ08049.1 | SKA53_02681 | SKA53_10004 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Precorrin-3B C17-methyltransferase region; COG2073 Cobalamin biosynthesis protein CbiG. | 0.971 |
| EAQ07266.1 | EAQ08050.1 | SKA53_02681 | SKA53_10009 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Cobalamin biosynthesis precorrin-2 methyltransferase; COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.975 |
| EAQ07266.1 | EAQ08051.1 | SKA53_02681 | SKA53_10014 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | CobL, precorrin-6Y C5,15-methyltransferase; COG2241 Precorrin-6B methylase 1. | 0.967 |
| EAQ07266.1 | EAQ08052.1 | SKA53_02681 | SKA53_10019 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | precorrin-8X methylmutase; COG2082 Precorrin isomerase. | 0.622 |
| EAQ07266.1 | EAQ08053.1 | SKA53_02681 | SKA53_10024 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Hypothetical protein. | 0.997 |
| EAQ07266.1 | EAQ08066.1 | SKA53_02681 | SKA53_10089 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | cobN protein; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | 0.535 |
| EAQ07266.1 | cbiD | SKA53_02681 | SKA53_03161 | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | cobalt-precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.776 |
| EAQ07363.1 | EAQ07266.1 | SKA53_03166 | SKA53_02681 | COG2099 Precorrin-6x reductase. | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.919 |
| EAQ07363.1 | EAQ08048.1 | SKA53_03166 | SKA53_09999 | COG2099 Precorrin-6x reductase. | COG2875 Precorrin-4 methylase. | 0.992 |
| EAQ07363.1 | EAQ08049.1 | SKA53_03166 | SKA53_10004 | COG2099 Precorrin-6x reductase. | Precorrin-3B C17-methyltransferase region; COG2073 Cobalamin biosynthesis protein CbiG. | 0.996 |