| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06061.1 | EAQ08150.1 | SKA53_08146 | SKA53_10509 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | Heat shock protein, Hsp70 family; COG0443 Molecular chaperone. | 0.516 |
| EAQ06061.1 | clpB | SKA53_08146 | SKA53_10369 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.755 |
| EAQ06061.1 | clpP | SKA53_08146 | SKA53_02121 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.479 |
| EAQ06061.1 | dnaJ | SKA53_08146 | SKA53_11638 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | Chaperone, DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.524 |
| EAQ06061.1 | dnaK | SKA53_08146 | SKA53_11628 | Hypothetical protein; COG0642 Signal transduction histidine kinase. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.516 |
| EAQ06172.1 | EAQ08150.1 | SKA53_08701 | SKA53_10509 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Heat shock protein, Hsp70 family; COG0443 Molecular chaperone. | 0.589 |
| EAQ06172.1 | clpB | SKA53_08701 | SKA53_10369 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.801 |
| EAQ06172.1 | dnaJ | SKA53_08701 | SKA53_11638 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Chaperone, DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.449 |
| EAQ06172.1 | dnaK | SKA53_08701 | SKA53_11628 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.600 |
| EAQ06172.1 | grpE | SKA53_08701 | SKA53_11833 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.597 |
| EAQ06890.1 | EAQ08150.1 | SKA53_15121 | SKA53_10509 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Heat shock protein, Hsp70 family; COG0443 Molecular chaperone. | 0.589 |
| EAQ06890.1 | clpB | SKA53_15121 | SKA53_10369 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.798 |
| EAQ06890.1 | dnaJ | SKA53_15121 | SKA53_11638 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Chaperone, DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.585 |
| EAQ06890.1 | dnaK | SKA53_15121 | SKA53_11628 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.713 |
| EAQ06890.1 | grpE | SKA53_15121 | SKA53_11833 | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.697 |
| EAQ08150.1 | EAQ06061.1 | SKA53_10509 | SKA53_08146 | Heat shock protein, Hsp70 family; COG0443 Molecular chaperone. | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.516 |
| EAQ08150.1 | EAQ06172.1 | SKA53_10509 | SKA53_08701 | Heat shock protein, Hsp70 family; COG0443 Molecular chaperone. | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | 0.589 |
| EAQ08150.1 | EAQ06890.1 | SKA53_10509 | SKA53_15121 | Heat shock protein, Hsp70 family; COG0443 Molecular chaperone. | Heat shock protein, Hsp20 family; COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | 0.589 |
| EAQ08150.1 | clpB | SKA53_10509 | SKA53_10369 | Heat shock protein, Hsp70 family; COG0443 Molecular chaperone. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.971 |
| EAQ08150.1 | clpP | SKA53_10509 | SKA53_02121 | Heat shock protein, Hsp70 family; COG0443 Molecular chaperone. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.708 |
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