| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ07907.1 | EAQ08123.1 | SKA53_09294 | SKA53_10374 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | COG0284 Orotidine-5'-phosphate decarboxylase. | 0.919 |
| EAQ07907.1 | EAQ08181.1 | SKA53_09294 | SKA53_10664 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Dihydropyrimidinase; COG0044 Dihydroorotase and related cyclic amidohydrolases. | 0.902 |
| EAQ07907.1 | EAQ08183.1 | SKA53_09294 | SKA53_10674 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | N-carbamoyl-L-amino acid amidohydrolase; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. | 0.551 |
| EAQ07907.1 | EAQ08185.1 | SKA53_09294 | SKA53_10684 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | COG0167 Dihydroorotate dehydrogenase. | 0.828 |
| EAQ07907.1 | EAQ08186.1 | SKA53_09294 | SKA53_10689 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Pyridine nucleotide-disulphide oxidoreductase family protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.490 |
| EAQ07907.1 | carA | SKA53_09294 | SKA53_07007 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | 0.924 |
| EAQ07907.1 | carB | SKA53_09294 | SKA53_09594 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | 0.958 |
| EAQ07907.1 | pyrB | SKA53_09294 | SKA53_14296 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | COG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.930 |
| EAQ07907.1 | pyrE | SKA53_09294 | SKA53_02601 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.990 |
| EAQ08123.1 | EAQ07907.1 | SKA53_10374 | SKA53_09294 | COG0284 Orotidine-5'-phosphate decarboxylase. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.919 |
| EAQ08123.1 | EAQ08181.1 | SKA53_10374 | SKA53_10664 | COG0284 Orotidine-5'-phosphate decarboxylase. | Dihydropyrimidinase; COG0044 Dihydroorotase and related cyclic amidohydrolases. | 0.835 |
| EAQ08123.1 | EAQ08185.1 | SKA53_10374 | SKA53_10684 | COG0284 Orotidine-5'-phosphate decarboxylase. | COG0167 Dihydroorotate dehydrogenase. | 0.936 |
| EAQ08123.1 | carA | SKA53_10374 | SKA53_07007 | COG0284 Orotidine-5'-phosphate decarboxylase. | COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | 0.938 |
| EAQ08123.1 | carB | SKA53_10374 | SKA53_09594 | COG0284 Orotidine-5'-phosphate decarboxylase. | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | 0.948 |
| EAQ08123.1 | pyrB | SKA53_10374 | SKA53_14296 | COG0284 Orotidine-5'-phosphate decarboxylase. | COG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.966 |
| EAQ08123.1 | pyrE | SKA53_10374 | SKA53_02601 | COG0284 Orotidine-5'-phosphate decarboxylase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.998 |
| EAQ08180.1 | EAQ08181.1 | SKA53_10659 | SKA53_10664 | ABC transporter, ATP-binding protein; COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component. | Dihydropyrimidinase; COG0044 Dihydroorotase and related cyclic amidohydrolases. | 0.879 |
| EAQ08180.1 | EAQ08183.1 | SKA53_10659 | SKA53_10674 | ABC transporter, ATP-binding protein; COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component. | N-carbamoyl-L-amino acid amidohydrolase; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. | 0.581 |
| EAQ08180.1 | EAQ08185.1 | SKA53_10659 | SKA53_10684 | ABC transporter, ATP-binding protein; COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component. | COG0167 Dihydroorotate dehydrogenase. | 0.689 |
| EAQ08180.1 | EAQ08186.1 | SKA53_10659 | SKA53_10689 | ABC transporter, ATP-binding protein; COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component. | Pyridine nucleotide-disulphide oxidoreductase family protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.491 |