| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06530.1 | EAQ06531.1 | SKA53_05563 | SKA53_05568 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.998 |
| EAQ06530.1 | EAQ06659.1 | SKA53_05563 | SKA53_13966 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.409 |
| EAQ06530.1 | EAQ07357.1 | SKA53_05563 | SKA53_03136 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.842 |
| EAQ06530.1 | EAQ07518.1 | SKA53_05563 | SKA53_11813 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.418 |
| EAQ06530.1 | EAQ08188.1 | SKA53_05563 | SKA53_10699 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.780 |
| EAQ06530.1 | ilvC | SKA53_05563 | SKA53_07047 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.989 |
| EAQ06530.1 | ilvE | SKA53_05563 | SKA53_10784 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.418 |
| EAQ06530.1 | leuA | SKA53_05563 | SKA53_09014 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.896 |
| EAQ06531.1 | EAQ06530.1 | SKA53_05568 | SKA53_05563 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.998 |
| EAQ06531.1 | EAQ06659.1 | SKA53_05568 | SKA53_13966 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.641 |
| EAQ06531.1 | EAQ07357.1 | SKA53_05568 | SKA53_03136 | COG0440 Acetolactate synthase, small (regulatory) subunit. | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.945 |
| EAQ06531.1 | EAQ07518.1 | SKA53_05568 | SKA53_11813 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.666 |
| EAQ06531.1 | EAQ08188.1 | SKA53_05568 | SKA53_10699 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.751 |
| EAQ06531.1 | ilvC | SKA53_05568 | SKA53_07047 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
| EAQ06531.1 | ilvE | SKA53_05568 | SKA53_10784 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.751 |
| EAQ06531.1 | leuA | SKA53_05568 | SKA53_09014 | COG0440 Acetolactate synthase, small (regulatory) subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.941 |
| EAQ06659.1 | EAQ06530.1 | SKA53_13966 | SKA53_05563 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.409 |
| EAQ06659.1 | EAQ06531.1 | SKA53_13966 | SKA53_05568 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.641 |
| EAQ06659.1 | EAQ07200.1 | SKA53_13966 | SKA53_02351 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0413 Ketopantoate hydroxymethyltransferase. | 0.768 |
| EAQ06659.1 | EAQ07357.1 | SKA53_13966 | SKA53_03136 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.914 |