purU-2 protein (Yoonia vestfoldensis SKA53) - STRING interaction network

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purU-2

Probable formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (286 aa)

Predicted Functional Partners:

glyA-2

0.926

fhs

0.857

folD

0.835

EAQ08234.1

0.786

EAQ08232.1

0.776

EAQ06946.1

0.746

EAQ07148.1

0.729

EAQ07926.1

0.729

EAQ07520.1

0.729

purH

0.726

Your Current Organism:

Yoonia vestfoldensis SKA53

NCBI taxonomy Id: 314232
Other names: Loktanella vestfoldensis SKA53, Y. vestfoldensis SKA53

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAQ06946.1	EAQ07520.1	SKA53_15401	SKA53_11823	Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Phosphate acetyltransferase; COG0281 Malic enzyme.	0.434
EAQ06946.1	EAQ07926.1	SKA53_15401	SKA53_09389	Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Phosphate acetyltransferase; COG0281 Malic enzyme.	0.434
EAQ06946.1	fhs	SKA53_15401	SKA53_08541	Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Formate--tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family.	0.959
EAQ06946.1	folD	SKA53_15401	SKA53_08536	Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.774
EAQ06946.1	glyA-2	SKA53_15401	SKA53_10924	Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.847
EAQ06946.1	purH	SKA53_15401	SKA53_12688	Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful).	0.826
EAQ06946.1	purU-2	SKA53_15401	SKA53_10914	Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Probable formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.746
EAQ07148.1	EAQ07520.1	SKA53_02091	SKA53_11823	Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.	Phosphate acetyltransferase; COG0281 Malic enzyme.	0.913
EAQ07148.1	EAQ07926.1	SKA53_02091	SKA53_09389	Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.	Phosphate acetyltransferase; COG0281 Malic enzyme.	0.913
EAQ07148.1	fhs	SKA53_02091	SKA53_08541	Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.	Formate--tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family.	0.588
EAQ07148.1	folD	SKA53_02091	SKA53_08536	Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.	folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.493
EAQ07148.1	glyA-2	SKA53_02091	SKA53_10924	Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.	Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.564
EAQ07148.1	purU-2	SKA53_02091	SKA53_10914	Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.	Probable formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.729
EAQ07520.1	EAQ06946.1	SKA53_11823	SKA53_15401	Phosphate acetyltransferase; COG0281 Malic enzyme.	Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.434
EAQ07520.1	EAQ07148.1	SKA53_11823	SKA53_02091	Phosphate acetyltransferase; COG0281 Malic enzyme.	Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit.	0.913
EAQ07520.1	EAQ07926.1	SKA53_11823	SKA53_09389	Phosphate acetyltransferase; COG0281 Malic enzyme.	Phosphate acetyltransferase; COG0281 Malic enzyme.	0.875
EAQ07520.1	fhs	SKA53_11823	SKA53_08541	Phosphate acetyltransferase; COG0281 Malic enzyme.	Formate--tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family.	0.423
EAQ07520.1	folD	SKA53_11823	SKA53_08536	Phosphate acetyltransferase; COG0281 Malic enzyme.	folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.511
EAQ07520.1	glyA-2	SKA53_11823	SKA53_10924	Phosphate acetyltransferase; COG0281 Malic enzyme.	Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.531
EAQ07520.1	purH	SKA53_11823	SKA53_12688	Phosphate acetyltransferase; COG0281 Malic enzyme.	Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful).	0.468