| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06399.1 | EAQ06533.1 | SKA53_04908 | SKA53_05578 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | 0.876 |
| EAQ06399.1 | ade | SKA53_04908 | SKA53_12133 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | COG1001 Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | 0.942 |
| EAQ06399.1 | amn | SKA53_04908 | SKA53_12138 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. | 0.445 |
| EAQ06399.1 | apt | SKA53_04908 | SKA53_08371 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.923 |
| EAQ06399.1 | deoD | SKA53_04908 | SKA53_14611 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | COG0813 Purine-nucleoside phosphorylase. | 0.935 |
| EAQ06399.1 | mtnP | SKA53_04908 | SKA53_08366 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.825 |
| EAQ06533.1 | EAQ06399.1 | SKA53_05578 | SKA53_04908 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.876 |
| EAQ06533.1 | EAQ07830.1 | SKA53_05578 | SKA53_08909 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | COG4630 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A. | 0.851 |
| EAQ06533.1 | EAQ07831.1 | SKA53_05578 | SKA53_08914 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | COG4631 Xanthine dehydrogenase, molybdopterin-binding subunit B. | 0.868 |
| EAQ06533.1 | ade | SKA53_05578 | SKA53_12133 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | COG1001 Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | 0.873 |
| EAQ06533.1 | amn | SKA53_05578 | SKA53_12138 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. | 0.887 |
| EAQ06533.1 | apt | SKA53_05578 | SKA53_08371 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.880 |
| EAQ06533.1 | mtnP | SKA53_05578 | SKA53_08366 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.810 |
| EAQ06928.1 | EAQ07830.1 | SKA53_15311 | SKA53_08909 | COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. | COG4630 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A. | 0.954 |
| EAQ06928.1 | EAQ07831.1 | SKA53_15311 | SKA53_08914 | COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. | COG4631 Xanthine dehydrogenase, molybdopterin-binding subunit B. | 0.786 |
| EAQ06928.1 | ade | SKA53_15311 | SKA53_12133 | COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. | COG1001 Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | 0.760 |
| EAQ06928.1 | deoD | SKA53_15311 | SKA53_14611 | COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. | COG0813 Purine-nucleoside phosphorylase. | 0.871 |
| EAQ07258.1 | EAQ07830.1 | SKA53_02641 | SKA53_08909 | COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. | COG4630 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A. | 0.976 |
| EAQ07258.1 | EAQ07831.1 | SKA53_02641 | SKA53_08914 | COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. | COG4631 Xanthine dehydrogenase, molybdopterin-binding subunit B. | 0.775 |
| EAQ07258.1 | ade | SKA53_02641 | SKA53_12133 | COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. | COG1001 Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | 0.760 |